Atrial substrate identification in patients with chronic atrial fibrillation using multivariate statistical models and multiple attributes from atrial electrograms

• Grant number: 17/00319-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2017
• End date: December 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Takashi Yoneyama
• Grantee: Tiago Paggi de Almeida
• Host Institution: Divisão de Engenharia Eletrônica (IEE). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
• Associated scholarship(s): 18/02251-4 - Characterizing persistent atrial fibrillation dynamics using computational models and recurrence quantification analysis - towards novel biomarkers for guiding therapy, BE.EP.PD

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia found in the clinical practice and is one of the main causes of stroke. It is known that the pulmonary veins (PVs) participate in AF initiation and perpetuation, and the PV isolation (PVI) performed by radiofrequency catheter ablation is effective in the therapy of the paroxysmal form of AF. PVI, however, is insufficient for persistent AF (persAF) therapy due to its complex underlying pathophysiology. Atrial regions hosting electrograms with fractionated activity (CFAEs) have been introduced as possible targets for persAF ablation, but inconsistent results have led to intense debate on the efficacy of CFAE-guided ablation as therapy for persAF. Consequently, the development of efficient methods for persAF treatment is of great interest for both clinical and scientific community. More specifically, the precise identification of atrial tissues responsible for the perpetuation of this arrhythmia is crucial for the development of new persAF ablative therapy. Recent studies have shown that not all atrial electrogram (AEG) fractionation correlates with AF perpetuation. However, these investigations have considered few, if not only one, attribute measured from the AEGs, which can be a limiting factor when investigating complex phenomenon such as AF. The present work will I) investigate multiple attributes measured from AEGs collected from persAF patients to discriminate different types of AEG fractionation and; II) correlate those AEGs with the underlying mechanisms of AF perpetuation using multivariate statistical models. (AU)

Scientific publications

(20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHU, GAVIN S.; LI, XIN; STAFFORD, PETER J.; VANHEUSDEN, FREDERIQUE J.; SALINET, JOAO L.; ALMEIDA, TIAGO P.; DASTAGIR, NAWSHIN; SANDILANDS, ALASTAIR J.; KIRCHHOF, PAULUS; SCHLINDWEIN, FERNANDO S.; et al. Simultaneous Whole-Chamber Non-contact Mapping of Highest Dominant Frequency Sites During Persistent Atrial Fibrillation: A Prospective Ablation Study. FRONTIERS IN PHYSIOLOGY, v. 13, p. 14-pg., 2022-03-16. (17/00319-8, 18/25606-2)

ALMEIDA, TIAGO P.; SORIANO, DIOGO C.; MASE, MICHELA; RAVELLI, FLAVIA; BEZERRA, ARTHUR S.; LI, XIN; CHU, GAVIN S.; SALINET, JOAO; STAFFORD, PETER J.; NG, G. ANDRE; et al. Unsupervised Classification of Atrial Electrograms for Electroanatomic Mapping of Human Persistent Atrial Fibrillation. IEEE Transactions on Biomedical Engineering, v. 68, n. 4, p. 1131-1141, APR 2021. (18/02251-4, 15/12799-9, 17/00319-8, 19/05192-1)

LUONGO, GIORGIO; SCHULER, STEFFEN; LUIK, ARMIN; ALMEIDA, TIAGO P.; SORIANO, DIOGO C.; DOSSEL, OLAF; LOEWE, AXEL. Non-Invasive Characterization of Atrial Flutter Mechanisms Using Recurrence Quantification Analysis on the ECG: A Computational Study. IEEE Transactions on Biomedical Engineering, v. 68, n. 3, p. 914-925, MAR 2021. (19/09512-0, 18/02251-4, 17/00319-8)

GODINHO, FABIO; FIM NETO, ARNALDO; BIANQUETI, BRUNO LEONARDO; DE LUCCAS, JULIA BALDI; VARJAO, EDUARDO; TERZIAN FILHO, PAULO ROBERTO; FIGUEIREDO, EBERVAL GADELHA; ALMEIDA, TIAGO PAGGI; YONEYAMA, TAKASHI; TAKAHATA, ANDRE KAZUO; et al. Spectral characteristics of subthalamic nucleus local field potentials in Parkinson's disease: Phenotype and movement matter. European Journal of Neuroscience, v. 53, n. 8, FEB 2021. (19/09512-0, 18/14285-0, 13/07559-3, 18/14283-8, 18/02251-4, 17/00319-8)

TIAGO PAGGI DE ALMEIDA; FERNANDO SOARES SCHLINDWEIN; JOÃO SALINET; XIN LI; GAVIN SHEN-WEI CHU; JIUN HAUR TUAN; PETER JAMES STAFFORD; G ANDRÉ NG; DIOGO COUTINHO SORIANO. The temporal stability of recurrence quantification analysis attributes from chronic atrial fibrillation electrograms. Res. Biomed. Eng., v. 34, n. 4, p. 337-349, 2018-10-00. (17/00319-8, 15/12799-9)

ALMEIDA, TIAGO P.; NOTHSTEIN, MARK; LI, XIN; MASE, MICHELA; RAVELLI, FLAVIA; SORIANO, DIOGO C.; BEZERRA, ARTHUR S.; SCHLINDWEIN, FERNANDO S.; YONEYAMA, TAKASHI; DOESSEL, OLAF; et al. Phase Singularities in a Cardiac Patch Model With a Non-conductive Fibrotic Area During Atrial Fibrillation. 2020 COMPUTING IN CARDIOLOGY, v. N/A, p. 4-pg., 2020-01-01. (17/00319-8, 19/05192-1, 18/02251-4, 19/09512-0)

ALMEIDA, TIAGO P.; UNGER, LAURA A.; SORIANO, DIOGO C.; LI, XIN; DOESSEL, OLAF; YONEYAMA, TAKASHI; LOEWE, AXEL; IEEE. Recurrence Quantification Analysis for Investigating Atrial Fibrillation Dynamics in a Heterogeneous Simulation Setup. 2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), v. N/A, p. 4-pg., 2019-01-01. (18/02251-4, 17/00319-8)

NETO, ARNALDO FIM; DE LUCCAS, JULIA BALDI; BIANQUETI, BRUNO LEONARDO; DA SILVA, LUIZ RICARDO; ALMEIDA, TIAGO PAGGI; TAKAHATA, ANDRE KAZUO; TEIXEIRA, MANOEL JACOBSEN; FIGUEIREDO, EBERVAL GADELHA; NASUTO, SLAWOMIR J.; GUIMARAES ROCHA, MARIA SHEILA; et al. Subthalamic low beta bursts differ in Parkinson's disease phenotypes. CLINICAL NEUROPHYSIOLOGY, v. 140, p. 14-pg., 2022-08-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8, 18/02251-4)

ALMEIDA, TIAGO P.; SCHLINDWEIN, FERNANDO S.; SALINET, JOAO L.; LI, XIN; CHU, GAVIN S.; TUAN, JIUN H.; STAFFORD, PETER J.; NG, G. ANDRE; SORIANO, DIOGO C.; IEEE. Deterministic Structures in Fractionated Atrial Electrograms During Human Persistent Atrial Fibrillation. 2021 COMPUTING IN CARDIOLOGY (CINC), v. 44, p. 4-pg., 2017-01-01. (17/00319-8)

ALMEIDA, TIAGO P.; SORIANO, DIOGO C.; LI, XIN; CHU, GAVIN S.; SALINET, JOAO L.; SCHLINDWEIN, FERNANDO S.; STAFFORD, PETER J.; NG, G. ANDRE; YONEYAMA, TAKASHI; IEEE. Unsupervised k-Mean Classification of Atrial Electrograms From Human Persistent Atrial Fibrillation. 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), v. 45, p. 4-pg., 2018-01-01. (18/02251-4, 17/00319-8)

LI, XIN; CHU, GAVIN S.; ALMEIDA, TIAGO P.; SALINET, JOAO L.; MISTRY, AMAR R.; VALI, ZAKARIYYA; STAFFORD, PETER J.; SCHLINDWEIN, FERNANDO S.; NG, G. ANDRE; IEEE. Dominant Frequency Variability Mapping for Identifying Stable Drivers During Persistent Atrial Fibrillation Using Non-Contact Mapping. 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), v. 45, p. 4-pg., 2018-01-01. (17/00319-8)

ALMEIDA, TIAGO P.; SCHLINDWEIN, FERNANDO S.; SALINET, JOAO; LI, XIN; CHU, GAVIN S.; TUAN, JIUN H.; STAFFORD, PETER J.; NG, G. ANDRE; SORIANO, DIOGO C.. Characterization of human persistent atrial fibrillation electrograms using recurrence quantification analysis. Chaos, v. 28, n. 8, AUG 2018. (17/00319-8)

FIM NETO, A.; DE LUCCAS, J. B.; BIANQUETI, B. L.; ROCHA, M. S.; NASUTO, S. J.; GODINHO, F.; SORIANO, D. C.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Beta Burst Dynamics Differs for Parkinson's Disease Phenotypes. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 6-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

DE LUCCAS, J. B.; BIANQUETI, B. L.; FIM NETO, A.; ROCHA, M. S.; TAKAHATA, A. K.; SORIANO, D. C.; GODINHO, F.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Field Potentials in Parkinson's Disease Encodes Motor Symptoms Severity and Asymmetry. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 7-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

LI, XIN; ALMEIDA, TIAGO P.; DASTAGIR, NAWSHIN; GUILLEM, MARIA S.; SALINET, JOAO; CHU, GAVIN S.; STAFFORD, PETER J.; SCHLINDWEIN, FERNANDO S.; NG, G. ANDRE. Standardizing Single-Frame Phase Singularity Identification Algorithms and Parameters in Phase Mapping During Human Atrial Fibrillation. FRONTIERS IN PHYSIOLOGY, v. 11, JUL 21 2020. (17/00319-8)

SALINET, JOAO; SCHLINDWEIN, FERNANDO S.; STAFFORD, PETER; ALMEIDA, TIAGO P.; LI, XIN; VANHEUSDEN, FREDERIQUE J.; GUILLEM, MARIA S.; NG, G. ANDRE; IEEE. Persistent Atrial Fibrillation Hierarchical Activation: from Highest DF Sites to Wave Fractionation at the Boundaries. 2021 COMPUTING IN CARDIOLOGY (CINC), v. 44, p. 4-pg., 2017-01-01. (17/11103-6, 17/00319-8)

LI, XIN; CHU, GAVIN S.; ALMEIDA, TIAGO P.; VANHEUSDEN, FREDERIQUE J.; SALINET, JOAO; DASTAGIR, NAWSHIN; MISTRY, AMAR R.; VALI, ZAKARIYYA; SIDHU, BHARAT; STAFFORD, PETER J.; et al. Automatic Extraction of Recurrent Patterns of High Dominant Frequency Mapping During Human Persistent Atrial Fibrillation. FRONTIERS IN PHYSIOLOGY, v. 12, MAR 12 2021. (17/00319-8)

FIM NETO, ARNALDO; DE LUCCAS, JULIA BALDI; BIANQUENTI, BRUNO LEONARDO; ALMEIDA, TIAGO PAGGI; ROCHA, MARIA SHEILA; YONEYAMA, TAKASHI; FRANCESCHI GODINHO, FABIO LUIZ; SORIANO, DIOGO COUTINHO; DIAZ, CAG; GONZALEZ, CC; et al. Estimation of Beta Burst Durations from Subthalamic Nucleus Local Field Potentials in Parkinson's Disease Through Hilbert and Continuous Wavelets Transforms. VIII LATIN AMERICAN CONFERENCE ON BIOMEDICAL ENGINEERING AND XLII NATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, v. 75, p. 6-pg., 2020-01-01. (18/14283-8, 18/14285-0, 13/07559-3, 17/00319-8)

LI, XIN; CHU, GAVIN S.; ALMEIDA, TIAGO P.; SALINET, JOAO L.; MISTRY, AMAR R.; VALI, ZAKARIYYA; STAFFORD, PETER J.; SCHLINDWEIN, FERNANDO S.; NG, G. ANDRE; IEEE. A k-Nearest Neighbours Classifier for Predicting Catheter Ablation Responses Using Noncontact Electrograms During Persistent Atrial Fibrillation. 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), v. 45, p. 4-pg., 2018-01-01. (17/00319-8)

BEZERRA, ARTHUR S.; YONEYAMA, TAKASHI; SORIANO, DIOGO C.; LUONGO, GIORGIO; LI, XIN; RAVELLI, FLAVIA; MASE, MICHELA; CHU, GAVIN S.; STAFFORD, PETER J.; SCHLINDWEIN, FERNANDO S.; et al. Optimizing Atrial Electrogram Classification Based on Local Ablation Outcome in Human Atrial Fibrillation. 2020 COMPUTING IN CARDIOLOGY, v. N/A, p. 4-pg., 2020-01-01. (18/02251-4, 19/09512-0, 17/00319-8)