COVID-19-associated fungal infections

Author(s)

Hoenigl, Martin ; Seidel, Danila ; Sprute, Rosanne ; Cunha, Cristina ; Oliverio, Matteo ; Goldman, Gustavo H. ; Ibrahim, Ashraf S. ; Carvalho, Agostinho

• Document type: Journal article
• Source: NATURE MICROBIOLOGY; v. 7, n. 8, p. 14-pg., 2022-08-01.

Abstract

Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an important complication in a substantial number of critically ill, hospitalized patients with COVID-19. Three groups of fungal pathogens cause co-infections in COVID-19: Aspergillus, Mucorales and Candida species, including Candida auris. Here we review the incidence of COVID-19-associated invasive fungal infections caused by these fungi in low-, middle- and high-income countries. By evaluating the epidemiology, clinical risk factors, predisposing features of the host environment and immunological mechanisms that underlie the pathogenesis of these co-infections, we set the scene for future research and development of clinical guidance. Hoenigl and colleagues review the epidemiology, immunology and clinical risk factors contributing to COVID-19-associated fungal infections. (AU)

• FAPESP's process: 16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence
• Grantee: Gustavo Henrique Goldman
• Support Opportunities: Research Projects - Thematic Grants