| Full text | |
| Author(s): |
Oliveira, Thais A. S.
;
Vieira, Tatiana M.
;
Esperandim, Viviane R.
;
Martins, Carlos H. G.
;
Magalhaes, Lizandra G.
;
Miranda, Mayker L. D.
;
Crotti, Antonio E. M.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | PHARMACEUTICALS; v. 15, n. 8, p. 11-pg., 2022-08-01. |
| Abstract | |
This study aimed to investigate the chemical composition as well as the antibacterial, antiparasitic, and cytotoxic potentialities of the Brazilian Chrysopogon zizanioides root essential oil (CZ-EO) In addition, CZ-EO cytotoxicity to LLCMK2 adherent epithelial cells was assessed. The major compounds identified in CZ-EO were khusimol (30.0 +/- 0.3%), beta-eudesmol (10.8 +/- 0.3%), alpha-muurolene (6.0 +/- 0.1%), and patchouli alcohol (5.6 +/- 0.2%). CZ-EO displayed optimal antibacterial activity against Prevotella nigrescens, Fusobacterium nucleatum, Prevotella melaninogenica, and Aggregatibacter actinomycetemcomitans, with Minimum Inhibitory Concentration (MIC) values between 22 and 62.5 mu g/mL and Minimum Bactericidal Concentration (MBC) values between 22 and 400 mu g/mL. CZ-EO was highly active against the L. amazonensis promastigote and amastigote forms (IC50 = 7.20 and 16.21 mu g/mL, respectively) and the T. cruzi trypomastigote form (IC50 = 11.2 mu g/mL). Moreover, CZ-EO showed moderate cytotoxicity to LLCMK2 cells, with CC50 = 565.4 mu g/mL. These results revealed an interesting in vitro selectivity of CZ-EO toward the L. amazonensis promastigote and amastigote forms (Selectivity Index, SI = 78.5 and 34.8, respectively) and the T. cruzi trypomastigote form (SI = 50.5) compared to LLCMK2 cells. These results showed the promising potential of CZ-EO for developing new antimicrobial, antileishmanial, and antitrypanosomal drugs. (AU) | |