Antibacterial and antifungal activities in vitro of a novel silver(I) complex with sulfadoxine-salicylaldehyde Schiff base

Author(s)

Oliveira, Igor Santos ; Manzano, Carlos Marrote ; Nakahata, Douglas Hideki ; Santiago, Mariana Brentini ; Silva, Nagela Bernadelli Sousa ; Martins, Carlos Henrique Gomes ; Respindula, Fernando Pimentel ; Pereira, Douglas Henrique ; Corbi, Pedro Paulo

• Document type: Journal article
• Source: Polyhedron; v. 225, p. 12-pg., 2022-08-04.

Abstract

Skin wound infections can be considered one of the most common causes of death in burned patients. The raising reports of multidrug resistant microorganisms reveals a complicated condition for the treatment of burn wound injuries, establishing urgency in the development of novel antimicrobial agents. Considering this scenario, the present work describes the synthesis, antibacterial and antifungal activities of a sulfadoxine-salicylaldehyde Schiff base (SFX-SL), and of its novel dimeric silver(I) complex (AgSFX-SL). Elemental analysis indicated a 1:1 metal:ligand molar composition for the AgSFX-SL complex, with the minimum formula AgC19H17N4O5S. Mass spectrometric (HRMS) data reveal the existence of dimeric species of the complex in solution. Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopic studies suggest coordination of the Schiff base to silver(I) by the nitrogen and oxygen atoms of the sulfonamide group. The structure of the SFX-SL Schiff base was determined by single crystal X-ray diffraction. Molecular modeling confirms the proposition of a dimeric structure for the AgSFX-SL complex as early indicated by mass spectrometric data. The AgSFX-SL complex showed an effective antimicrobial activity over pathogens including Gram-positive Staphylococcus aureus (multidrug resistant), S. epidermidis, Cutibacterium acnes, and Gram-negative Pseudomonas aeruginosa and Bur-kholderia cepacia, with minimum inhibitory concentration (MIC) values in the range 12.0-48.0 mu mol.L- 1. Additionally, the AgSFX-SL complex was active against Candida albicans with a MIC value of 2.8 mu mol.L- 1. Electrophoresis assays showed that the AgSFX-SL complex does not interact with protein models lysozyme and bovine serum albumin (BSA). (AU)

• FAPESP's process: 17/25995-6 - New Ag(I), Pd(II) and Pt(II) metal complexes with ligands used for the treatment of Tuberculosis: synthesis and in vitro evaluation of antimicrobial and antiproliferative activities
• Grantee: Carlos Marrote Manzano
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/12062-4 - Synthesis, characterization and studies of interaction with biomolecules of metal complexes containing biologically active ligands: a strategy in the preparation of new agents with antibacterial and antiviral activities
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/08717-8 - Synthesis of copper, silver and gold complexes involving nucleotide analogues in the search of new alternatives for the treatment of ovarian cancer
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants