Role of arterial stiffness and endothelial dysfunction on lower limb performance in older adults with type 2 diabetes: A cross-sectional study

Author(s)

Heubel, Alessandro Domingues ; Kabbach, Erika Zavaglia ; Migliato, Guilherme Romano ; Russo, Maria Isabella Santos ; Brandao, Gustavo Mucoucah Sampaio ; Roscani, Meliza Goi ; Borghi-Silva, Audrey ; Mendes, Renata Goncalves

• Document type: Journal article
• Source: JOURNAL OF DIABETES AND ITS COMPLICATIONS; v. 36, n. 8, p. 6-pg., 2022-08-04.

Abstract

Aim: To verify whether arterial stiffness and endothelial dysfunction influence lower limb muscle strength and gait speed in older adults with type 2 diabetes mellitus (T2DM).Methods: Cross-sectional study including seventy-eight older adults with T2DM (aged 67 +/- 6 years and 42 % male). Arterial stiffness was assessed using pulse wave velocity (PWV), while endothelial function was measured by flow-mediated dilation (FMD). Lower limb muscle strength and gait speed were assessed using the 30-second chair stand test (30s-CST) and 10-Meter Walk Test, respectively.Results: Both PWV (m/s) and FMD (%) were univariately associated with number of repetitions in 30s-CST and gait speed (P < 0.05). After control for age, sex and body mass index, PWV remained associated with repetitions in 30s-CST (95 % CI:-0.494 to-0.054; P = 0.015) and gait speed (95 % CI:-0.039 to-0.002; P = 0.031). After adjustments for control variables, T2DM duration and glycemic control, FMD was associated with repetitions in 30s-CST (95 % CI: 0.008 to 0.324; P = 0.039) and gait speed (95 % CI: 0.011 to 0.038; P = 0.001).Conclusion: In older adults with T2DM, both arterial stiffness and endothelial dysfunction are associated with decreased leg muscle strength and slower gait speed. (AU)

• FAPESP's process: 17/19853-4 - Influence of glycemic control in arterial stiffness and functional performance in elderly with type 2 Diabetes
• Grantee: Guilherme Romano Migliato
• Support Opportunities: Scholarships in Brazil - Scientific Initiation