Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia

Author(s):Show less -

Pereira-Martins, Diego A. ; Coelho-Silva, Juan L. ; Weinhauser, Isabel ; Franca-Neto, Pedro L. ; Silveira, Douglas R. ; Ortiz, Cesar ; Moreira-Aguiar, Amanda ; Lima, Marinus M. ; Koury, Luisa C. ; de Melo, Raul A. ; Gloria, Ana B. ; Fagundes, Evandro M. ; Lino, Bruno K. ; Pagnano, Katia ; Bittencourt, Rosane ; Nunes, Elenaide ; Traina, Fabiola ; Figueiredo-Pontes, Lorena ; Keating, Armand ; Tallman, Martin S. ; Ribeiro, Raul C. ; Dilon, Richard ; Ganser, Arnold ; Sanz, Miguel A. ; Berliner, Nancy ; Valk, Peter ; Lowenberg, Bob ; Ottone, Tiziana ; Noguera, Nelida, I ; Voso, Maria T. ; Paoloni, Francesca ; Fazi, Paola ; Ammatuna, Emanuele ; Huls, Gerwin ; Schuringa, Jan Jacob ; Rego, Eduardo M. ; Lucena-Araujo, Antonio R.

• Document type: Journal article
• Source: British Journal of Haematology; v. 200, n. 2, p. 5-pg., 2022-10-20.

Abstract

Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA. (AU)

• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/23191-4 - Investigation of IRS2 role on the pathogenesis of myeloproliferative neoplasms JAK2V617F using murine models
• Grantee: Juan Luiz Coelho da Silva
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/09228-0 - Detection and functional analysis of Tumor-Associated Macrophages (TAM) in a transgenic model of acute promyelocytic leukemia (APL).
• Grantee: Isabel Weinhauser
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/23117-1 - Evaluation of TP53/TP73 pathway in engraftment of acute promyelocytic leukemia cells in xenotransplantation model
• Grantee: Diego Antonio Pereira Martins
• Support Opportunities: Scholarships in Brazil - Doctorate