A 58S bioactive glass for dentin hypersensitivity and erosive tooth wear: An in vitro study

Author(s)

Viana, Itallo Emidio Lira ; Borges, Roger ; Marchi, Juliana ; Feitosa, Sabrina ; Marques, Marcia Martins ; Scaramucci, Tais

• Document type: Journal article
• Source: Journal of Dentistry; v. 127, p. 9-pg., 2022-10-26.

Abstract

Objectives: To assess the effect of an experimental 58S bioactive glass on dentin permeability (dP) and erosive tooth wear (dentin surface loss -dSL).Methods: 58S bioactive glass was synthetized using a sol-gel methodology, following by lyophilization and calcination, then mixed with phosphoric acid to obtain a paste (BGP). Forty-eight dentin disks (1 mm-thick) were used for dP, and 48 dentin slabs (3 mm x 3 mm) for dSL, which were assessed at three time intervals: post-EDTA (5 min in 17% EDTA solution); post-treatment (C: distilled water; BGP: experimental bioactive glass paste; NP: Nupro prophylaxis paste; CXT: Clinpro XT varnish); and post-erosive/abrasive cycling. Data were statistically analyzed (alpha=0.05).Results: For dP and dSL, Groups did not differ significantly post-EDTA (p>0.05). Post-treatment, all groups showed lower dP than C (p<0.05), without differing significantly among them. For the dSL analysis, Groups C, BGP and NP did not differ significantly, showing lower values than CXT (p<0.05). Post-cycling, C continued to show the highest dP (p<0.05). Specimens from Group CXT had the lowest dP and did not differ from NP (p=0.86) which did not differ from BGP (p=0.193). For C and BGP, dP value was higher post-cycling than post-treatment (p<0.05). For NP and CXT, these experimental times did not differ (p>0.05). Post-cycling, dSL for C, BGP and NP did not differ significantly; values were higher than those for CXT (p<0.05).Conclusions: BGP reduced dP after application, with a reduced effect after cycling. Nonetheless, it was not able to protect dentin against erosive tooth wear.Clinical Significance: Minimizing dentin hypersensitivity is a challenge in the field of dentistry. The development of alternative products with potential to obliterate dentinal tubules and provide resistance to chemical/me-chanical stimuli is, thus, highly desirable. We have proposed a material able to reduce dentin permeability, which has emerged as a promising alternative for this purpose. (AU)

• FAPESP's process: 19/00549-9 - Evaluation of surface loss and tubular occlusion of dentin, and cell differentiation with different in-office treatments for dentin hypersensitivity, associated or not with photobiomodulation therapy
• Grantee: Ítallo Emídio Lira Viana
• Support Opportunities: Scholarships in Brazil - Doctorate