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Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes

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Author(s):
de Souza, Wanderson C. C. ; Lima, Rafaely N. N. ; de Jesus, Iva S. S. ; Correia, Jose Tiago M. ; Paixao, Marcio W.
Total Authors: 5
Document type: Journal article
Source: SYNTHESIS-STUTTGART; v. N/A, p. 10-pg., 2022-12-20.
Abstract

A deaminative alkyl radical cascade cyclization of 1,7dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection of cyclopentaquinolinones. (AU)

FAPESP's process: 21/06099-5 - Development of new photochemical methodologies for the synthesis of small molecule and biomolecule modifications
Grantee:Márcio Weber Paixão
Support Opportunities: Regular Research Grants