Role of Endothelial Cells in Hematological Malignancies

Author(s)

Gomes Pereira, Illy Enne ; Cacemiro, Maira da Costa ; Cominal, Jucara Gastaldi ; Barretto, Gabriel Dessotti ; de Castro, Fabiola Attie

• Document type: Journal article
• Source: EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY; v. 6, n. 3, p. 9-pg., 2022-01-01.

Abstract

Endothelial cells (EC) are key elements of vascularized tissues that form a single-cell layer that connects the vessels to the surrounding tissues. EC participate in the regulation of blood hemostasis, leukocyte homing, acute inflammation, wound healing, and antigen presentation. EC subpopulations are characterized by diverse structures, functions, and molecular profiles. In bone marrow, EC are part of the hematopoietic stem cell vascular and endosteal niche, where they play well-defined roles in hematopoietic stem cell functioning and maintenance, and reside surrounding sinusoids and blood vessels. In the past years, the clinical and pathophysiological roles of EC have been explored due to their contribution to neoangiogenesis and alterations in the vascular endothelium functions in hematological diseases. The present review discusses the EC contribution to pathogenesis of hematological malignancies and their potential use as therapeutic target in these diseases. (AU)

• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/19714-7 - Bone Marrow Mesenchymal Stromal Cells deregulation effect on BCR-ABL1-Myeloproliferative Neoplasms pathophysiology and progression
• Grantee: Fabíola Attié de Castro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/01756-5 - Immunological and Functional Characterization of Multipotent Mesenchymal Stromal Cells in Myeloproliferative Neoplasms
• Grantee: Maira da Costa Cacemiro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Projects - Thematic Grants