Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

Author(s)

Floriano, Juliana Ferreira ; Barbosa, Angelica Mercia Pascon ; de Oliveira, Rafael Guilen ; Vega, Sofia ; Catinelli, Bruna Bologna ; Garcia, Gabriela Azevedo ; Reyes, David Rafael ; Sobrevia, Luis ; Rudge, Marilza Vieira Cunha ; DIAMATER Study Grp

• Document type: Journal article
• Source: Placenta; v. 130, p. 4-pg., 2022-11-11.

Abstract

Induction of diabetes mellitus by streptozotocin (STZ) in rats at birth is of high mortality and low success rate when male puppies are separated from females, prioritizing females breastfeeding. Cross-parental care of the entire litter and SZT-induced diabetes up to 12 h post-birth become with high success rate, low animal death, and females with glycaemia > 140 mg/dL on the 90 postnatal day. Cross-parental care is more effective in STZ-induction of diabetes, which is maintained during pregnancy (diabetes in pregnancy), than the conventional protocol of male separation at birth. (AU)

• FAPESP's process: 17/21783-4 - Gestational triad cohort: hyperglycemia, urinary incontinence and clinical, molecular and omic profile of hyperglycemic myopathy in predicting incontinence and muscle dysfunction and translational research with biodevice for muscle regeneration in rats
• Grantee: Juliana Ferreira Floriano
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats
• Grantee: Marilza Vieira Cunha Rudge
• Support Opportunities: Research Projects - Thematic Grants