| Full text | |
| Author(s): |
Oliveira, Isadora
;
Costa, Victor
;
Veras, Flavio
;
Ferreira, Isabela
;
Cunha, Fernando
;
Cunha, Thiago
;
Monteiro, Wuelton
;
Arantes, Eliane
;
Pucca, Manuela
Total Authors: 9
|
| Document type: | Journal article |
| Source: | TOXINS; v. 15, n. 1, p. 5-pg., 2023-01-01. |
| Abstract | |
Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about CdcPDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases. (AU) | |
| FAPESP's process: | 20/13176-3 - Human monoclonal antibodies (scFv) discovery with cross-reactivity and pH-dependent to metalloproteases from Bothrops spp |
| Grantee: | Isadora Sousa de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/10173-6 - Production, modification and characterization of animal toxins with potential biotechnological application |
| Grantee: | Eliane Candiani Arantes Braga |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/08216-2 - CRID - Center for Research in Inflammatory Diseases |
| Grantee: | Fernando de Queiroz Cunha |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |