SGC-CAMKK2-1: A Chemical Probe for CAMKK2

Author(s):Show less -

Wells, Carrow ; Liang, Yi ; Pulliam, Thomas L. ; Lin, Chenchu ; Awad, Dominik ; Eduful, Benjamin ; O'Byrne, Sean ; Hossain, Mohammad Anwar ; Catta-Preta, Carolina Moura Costa ; Ramos, Priscila Zonzini ; Gileadi, Opher ; Gileadi, Carina ; Counago, Rafael M. ; Stork, Brittany ; Langendorf, Christopher G. ; Nay, Kevin ; Oakhill, Jonathan S. ; Mukherjee, Debarati ; Racioppi, Luigi ; Means, Anthony R. ; York, Brian ; McDonnell, Donald P. ; Scott, John W. ; Frigo, Daniel E. ; Drewry, David H.

• Document type: Journal article
• Source: CELLS; v. 12, n. 2, p. 17-pg., 2023-01-01.

Abstract

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2. (AU)

• FAPESP's process: 13/50724-5 - Protein Kinase Chemical Biology Center: supporting drug development through open-access research
• Grantee: Paulo Arruda
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• FAPESP's process: 14/50897-0 - INCT 2014: Open-acess Medicinal Chemistry Centre (OpenMedChem)
• Grantee: Katlin Brauer Massirer
• Support Opportunities: Research Projects - Thematic Grants