Is type 2 diabetes mellitus another intercellular junction-related disorder?

Author(s)

Collares-Buzato, Carla B. ; Carvalho, Carolina P. F.

• Document type: Journal article
• Source: Experimental Biology and Medicine; v. 247, n. 9, p. 13-pg., 2022-04-23.

Abstract

Type 2 diabetes mellitus (T2D) is nowadays a worldwide epidemic and has become a major challenge for health systems around the world. It is a multifactorial disorder, characterized by a chronic state of hyperglycemia caused by defects in the production as well as in the peripheral action of insulin. This minireview highlights the experimental and clinical evidence that supports the novel idea that intercellular junctions (IJs)-mediated cell-cell contacts play a role in the pathogenesis of T2D. It focuses on IJs repercussion for endocrine pancreas, intestinal barrier, and kidney dysfunctions that contribute to the onset and evolution of this metabolic disorder. (AU)

• FAPESP's process: 18/02118-2 - Role of the tight junction-mediated intestinal epithelial barrier in the pathogenesis of type 2 diabetes mellitus and the effect of butyrate treatment using in vivo and in vitro models.
• Grantee: Carla Beatriz Collares Buzato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/22206-2 - Role of the adherens and gap junctions for the endocrine pancreas function of mice in the onset of type 2 prediabetes
• Grantee: Carolina Prado de França Carvalho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/15676-0 - In vitro modulation of intestinal epithelial barrier mediated by tight junctions: effect of exposure to nutrients (glucose and fatty acids), insulin and bacterial microbiota of prediabetic animals
• Grantee: Carla Beatriz Collares Buzato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/50789-1 - Role of cell-cell contacts mediated by intercellular junctions and their constitutive proteins in the functional maturation and dysfunction of pancreatic beta cells
• Grantee: Carla Beatriz Collares Buzato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/25442-1 - Role of the canonical and non-canonical Wnt signaling pathway in the beta cell function and proliferation during experimental prediabetes
• Grantee: Carla Beatriz Collares Buzato
• Support Opportunities: Regular Research Grants