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Role of cell-cell contacts mediated by intercellular junctions and their constitutive proteins in the functional maturation and dysfunction of pancreatic beta cells

Grant number: 10/50789-1
Support Opportunities:Regular Research Grants
Duration: July 01, 2010 - December 31, 2012
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Carla Beatriz Collares Buzato
Grantee:Carla Beatriz Collares Buzato
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Intercellular junctions are specializations of the plasma membrane that allow cells within a tissue to interact and adhere to each other. In endocrine pancreas, the different endocrine cells are interconnected by tight, gap and adherens-type junctions. Such intercellular contacts seem to be crucial for this organ functioning, however, little is known about the pathophysiological role and biochemistry of intercellular junctions (Us) in the endocrine pancreas. The general aim of this project is to study the importance of cell-cell recognition and adhesion mediated by proteins associated to tight and adherens junctions in pancreatic islets, with emphasis on the process of insulin secretion, along the animal development and in the pathogenesis of type 2 diabetes. For that, animal models will be used and the structure and function of the Us in the pancreatic beta cells will be evaluated by immunohistochemistry, immunoblotting and biochemical methods. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, R. B.; MASCHIO, D. A.; CARVALHO, C. P. F.; COLLARES-BUZATO, C. B.. Influence of gender and time diet exposure on endocrine pancreas remodeling in response to high fat diet-induced metabolic disturbances in mice. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, v. 200, p. 88-97, . (10/50789-1, 09/52824-1)
D OLIVEIRA, RICARDO B.; CARVALHO, CAROLINA P. D. F.; POLO, CARLA C.; DORIGHELLO, GABRIEL D. G.; BOSCHERO, ANTONIO C.; D OLIVEIRA, HELENA C. F.; COLLARES-BUZATO, CARLA B.. Impaired compensatory beta-cell function and growth in response to high-fat diet in LDL receptor knockout mice. International Journal of Experimental Pathology, v. 95, n. 4, p. 296-308, . (10/50789-1, 09/52824-1)
COLLARES-BUZATO, CARLA B.; CARVALHO, CAROLINA P. F.. Is type 2 diabetes mellitus another intercellular junction-related disorder?. Experimental Biology and Medicine, v. 247, n. 9, p. 13-pg., . (18/02118-2, 14/22206-2, 13/15676-0, 10/50789-1, 15/25442-1)
CARVALHO, C. P. F.; OLIVEIRA, R. B.; BRITAN, A.; SANTOS-SILVA, J. C.; BOSCHERO, A. C.; MEDA, P.; COLLARES-BUZATO, C. B.. Impaired beta-cell-beta-cell coupling mediated by Cx36 gap junctions in prediabetic mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 303, n. 1, p. E144-E151, . (10/50789-1, 09/52824-1)
SANTOS-SILVA, JUNIA CAROLINA; DE FRANCA CARVALHO, CAROLINA PRADO; DE OLIVEIRA, RICARDO BELTRAME; BOSCHERO, ANTONIO CARLOS; COLLARES-BUZATO, CARLA BEATRIZ. Cell-to-cell contact dependence and junctional protein content are correlated with in vivo maturation of pancreatic beta cells. Canadian Journal of Physiology and Pharmacology, v. 90, n. 7, p. 837-850, . (10/50789-1)
FALCAO, VIVIANE TANNURI F. L.; MASCHIO, DANIELA A.; DE FONTES, CAMILA CALVO; OLIVEIRA, RICARDO B.; SANTOS-SILVA, JUNIA C.; SOARES ALMEIDA, ANNA CAROLINA; VANZELA, EMERIELLE C.; CARTAXO, MARIA TEREZA; CARVALHO, CAROLINA P. F.; COLLARES-BUZATO, CARLA BEATRIZ. Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMs) in diabetic mice after prolonged high-fat diet. Histochemistry and Cell Biology, v. 146, n. 1, p. 13-31, . (10/50789-1, 09/54129-9)

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