| Full text | |
| Author(s): Show less - |
Scariot, Rafaela
;
Brunet, Leonardo
;
Olsson, Bernardo
;
Palinkas, Marcelo
;
Hallak Regalo, Simone Cecilio
;
Barbosa Rebellato, Nelson Luis
;
Brancher, Joao Armando
;
Torres, Carolina Paes
;
Diaz-Serrano, Kranya Victoria
;
Kuchler, Erika Calvano
;
Zielak, Joao Cesar
Total Authors: 11
|
| Document type: | Journal article |
| Source: | CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE; v. 40, n. 2, p. 8-pg., 2019-12-25. |
| Abstract | |
Objective: To evaluate the association of bruxism phenotypes with single nucleotide polymorphisms in FKBP5, DRD2, ANKK1, and COMT. Methods: Clinical oral examination was performed to diagnose bruxism phenotypes in 150 children. DNA was collected from saliva. Logistic univariate regression, Chi-square, and Fisher's exact tests were performed (p < 0.05). Results: Bruxism was associated with DRD2 (p = 0.02). Tooth grinding while awake was associated with ANKK1 (p < 0.001), and tooth grinding while asleep was associated with DRD2 in the additive (p = 0.030) and dominant (p = 0.008) model. Tooth clenching while awake was associated with ANKK1 in the additive (p = 0.005) and dominant (p = 0.008) models, whereas tooth clenching while asleep was associated with ANKK1 (p < 0.001) and with COMT in the additive (p = 0.001) and dominant (p = 0.003) models. Discussion: Polymorphisms in DRD2, ANKK1, and COMT are associated with bruxism phenotypes. (AU) | |
| FAPESP's process: | 15/06866-5 - Evaluation of the role of estrogen in dentofacial development |
| Grantee: | Erika Calvano Kuchler |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/08149-1 - Evaluation of the role of estrogen in dentofacial tissues |
| Grantee: | Erika Calvano Kuchler |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |