Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential

Author(s):Show less -

Marena, Gabriel Davi ; Girotto, Luiza ; Saldanha, Luiz Leonardo ; Ramos, Matheus Aparecido dos Santos ; De Grandis, Rone Aparecido ; da Silva, Patricia Bento ; Dokkedal, Anne Ligia ; Chorilli, Marlus ; Bauab, Tais Maria ; Pavan, Fernando Rogerio ; Trovatti, Eliane ; Lustri, Wilton Rogerio ; Resende, Flavia Ap.

• Document type: Journal article
• Source: Planta Medica; v. 88, n. 05, p. 11-pg., 2021-01-28.

Abstract

Myrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M. bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M. bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M. bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M. bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp. (AU)

• FAPESP's process: 17/18782-6 - Click chemistry platform for the development of polymer-based materials for regenerative medicine
• Grantee: Eliane Trovatti
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/16278-9 - Study of the genotoxicological potential and permeation assay with Caco-2 cells of metallic complexes with promising biological activities
• Grantee: Flávia Aparecida Resende Nogueira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/12590-0 - Synthesis of metal complexes with bioactive N,N or N,O-coordinating ligands for use in sustainable delivery system based on bacterial cellulose
• Grantee: Wilton Rogério Lustri
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/08559-5 - Chemical analyze and therapeutic prospection of Syngonanthus nitens (Bong.) Ruhland and Cymbopogon nardus (L.) Rendle loaded into nanotechnological systems applied to vulvovaginal candidiasis treatment
• Grantee: Taís Maria Bauab
• Support Opportunities: Regular Research Grants