Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size

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Gerber, Jennifer Tsi ; Weiss, Suyany Gabriely ; Mijolaro, Laura Vidal ; Silva, Carolina Siqueira ; Petinati, Maria Fernanda Pivetta ; Meger, Michelle Nascimento ; Honorio, Heitor Marques ; Rebellato, Nelson Luis Barbosa ; Sebastiani, Aline Monise ; Kuchler, Erika Calvano ; Scariot, Rafaela

• Document type: Journal article
• Source: ORTHODONTICS & CRANIOFACIAL RESEARCH; v. 26, n. 4, p. 7-pg., 2023-03-07.

Abstract

Background: The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response.Materials and Methods: This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.Results: In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P < .05). In the BL dimension, the sex, dental group, dental arch and polymorphism in rs694 and rs307247 were associated with variation in TCS.Conclusions: In short, this study suggests that genetic polymorphisms of PTH are associated with variations in the BL TCS of permanent human teeth. (AU)

• FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
• Grantee: Erika Calvano Kuchler
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/08149-1 - Evaluation of the role of estrogen in dentofacial tissues
• Grantee: Erika Calvano Kuchler
• Support Opportunities: Scholarships in Brazil - Young Researchers