| Full text | |
| Author(s): |
Cruz, Vitoria Maria Sousa
;
Perez-de-Oliveira, Maria Eduarda
;
Leite, Eder Gerardo dos Santos
;
Louredo, Brendo Vinicius Rodrigues
;
Bezerra, Helen Kaline Farias
;
Lopes, Marcio Ajudarte
;
Vargas, Pablo Agustin
;
Santos-Silva, Alan Roger
;
Kowalski, Luiz Paulo
;
Perez, Danyel Elias da Cruz
Total Authors: 10
|
| Document type: | Journal article |
| Source: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 45, n. 8, p. 13-pg., 2023-06-26. |
| Abstract | |
Sialoblastoma is a rare malignant salivary gland tumor. The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (n = 28; 45.2%). In the log-rank test, there was a significant increase in disease-associated survival in patients younger than 1 year of age (82.8% vs. 44.4%; p = 0.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; p = 0.005), patients without metastases (77.8% vs. 14.3%; p = 0.011), encapsulated lesions (85.7% vs. 0%; p < 0.0001), congenital lesions (83.3% vs. 25.0%; p < 0.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; p = 0.035). Kaplan-Meier curves estimated overall survival and disease-free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR] = 9.81; p = 0.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate. (AU) | |
| FAPESP's process: | 22/01257-4 - Disrupting tumor resistance through therapy targeting depletion of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma patient-derived xenograft |
| Grantee: | Brendo Vinicius Rodrigues Louredo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/09692-9 - Validation of target proteins associated with the progression of potentially malignant disorders into Oral Cancer |
| Grantee: | Ana Gabriela Costa Normando |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 21/10810-6 - Proximity-Dependent Biotinylation for the identification of interacting proteins in salivary gland cells harbouring the CRTC1-MAML2 translocation |
| Grantee: | Maria Eduarda Pérez de Oliveira |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |