Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response

Author(s)

Londe, Ana Carolina ; Fernandez-Ruiz, Ruth ; Julio, Paulo Rogerio ; Appenzeller, Simone ; Niewold, Timothy B.

• Document type: Journal article
• Source: JOURNAL OF RHEUMATOLOGY; v. 50, n. 9, p. 11-pg., 2023-09-01.

Abstract

Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage. We will review the role and potential drivers of IFN-I dysregulation in 5 prototypic autoimmune diseases: systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, primary Sjogren syndrome, and systemic sclerosis. We will also discuss current therapeutic strategies that directly or indirectly target the IFN-I system. (AU)

• FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/23269-3 - MicroRNAs of TNFa gene in systemic lupus erythematosus: potential biomarkers
• Grantee: Mariana Postal Zink de Souza
• Support Opportunities: Scholarships in Brazil - Post-Doctoral