| Full text | |
| Author(s): |
Santos, Thays Brenner
;
Kramer-Soares, Juliana Carlota
;
Coelho, Cesar Augusto de Oliveira
;
Menezes Oliveira, Maria Gabriela
Total Authors: 4
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 13, n. 1, p. 23-pg., 2023-08-11. |
| Abstract | |
In fear conditioning with time intervals between the conditioned (CS) and unconditioned (US) stimuli, a neural representation of the CS must be maintained over time to be associated with the later US. Usually, temporal associations are studied by investigating individual brain regions. It remains unknown, however, the effect of the interval at the network level, uncovering functional connections cooperating for the CS transient memory and its fear association. We investigated the functional network supporting temporal associations using a task in which a 5-s interval separates the contextual CS from the US (CFC-5s). We quantified c-Fos expression in forty-nine brain regions of male rats following the CFC-5s training, used c-Fos correlations to generate functional networks, and analyzed them by graph theory. Control groups were trained in contextual fear conditioning, in which CS and US overlap. The CFC-5s training additionally activated subdivisions of the basolateral, lateral, and medial amygdala; prelimbic, infralimbic, perirhinal, postrhinal, and intermediate entorhinal cortices; ventral CA1 and subiculum. The CFC-5s network had increased amygdala centrality and higher amygdala internal and external connectivity with the retrosplenial cortex, thalamus, and hippocampus. Amygdala and thalamic nuclei were network hubs. Functional connectivity among these brain regions could support CS transient memories and their association. (AU) | |
| FAPESP's process: | 16/13027-2 - Neural network underlying fear conditioning acquisition with temporal and spatial discontinuity: interactions of prelimbic cortex |
| Grantee: | Thays Brenner dos Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/04844-5 - Identification of neuronal ensembles in fear conditioning with temporal and contextual components |
| Grantee: | Thays Brenner dos Santos |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 16/25755-2 - Neural network underlying fear conditioning acquisition with temporal and spatial discontinuity: interactions of prelimbic cortex |
| Grantee: | Maria Gabriela Menezes de Oliveira |
| Support Opportunities: | Regular Research Grants |