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Temporal dynamics of memory modulation by corticosterone


Several studies have shown that glucocorticoids (cortisol in humans and corticosterone - CORT - in rats), released during emotional or stressful situations, improve memory. The CORT hormone acts in different brain regions, including the hippocampus, to increase the consolidation of various types of memory tasks, such as the contextual fear conditioning (CFC). Some evidence indicates that the hippocampus has a limited temporal role in the processing of memories, which, over time, become stabilized and stored in the neocortex, with a consequent reduction in their specificity. Despite emotional memories being always referred to as well remembered for long periods of time, there are no studies that have investigated the temporal dynamics of CORT induced modulation of memory specificity and duration. This project will investigate the role of plasmatic CORT, released after different CFC training intensities, on the specificity and duration of contextual memory in rats. The possible involvement of different brain regions, such as the hippocampus, amygdala and cerebral cortex, in the retrieval of recent and remote CFC memory, induced by different training intensities, will also be examined. Moreover, the involvement of glucocorticoid receptors, immediately after training, in the specificity and duration of contextual memory will be analyzed. The results will, therefore, help to increase our knowledge about the behavioral, biochemical and neuroanatomical mechanisms involved in the effects of emotion and/or alert, on the formation and maintenance of long-term memory. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORREA, MOISES DOS SANTOS; VAZ, BARBARA DOS SANTOS; VIEIRA GRISANTI, GABRIEL DAVID; QUEIROZ DE PAIVA, JOSELISA PERES; TIBA, PAULA AYAKO; FORNARI, RAQUEL VECCHIO. Relationship between footshock intensity, post-training corticosterone release and contextual fear memory specificity over time. PSYCHONEUROENDOCRINOLOGY, v. 110, DEC 2019. Web of Science Citations: 0.

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