| Full text | |
| Author(s): |
Geraldino, Thais Herrero
;
Modiano, Patricia
;
Veronez, Luciana Chain
;
Floria-Santos, Milena
;
Garcia, Sergio Britto
;
Pereira-da-Silva, Gabriela
Total Authors: 6
|
| Document type: | Journal article |
| Source: | BIOMED RESEARCH INTERNATIONAL; v. 2017, p. 10-pg., 2017-01-01. |
| Abstract | |
Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies. Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects. The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity. To evaluate jacalin's potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis. Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N'-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 mu g) three times a week (on alternate weekdays) for 10 weeks. We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice. This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-alpha Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer. (AU) | |
| FAPESP's process: | 09/12046-0 - Effects of jacalin on experimental colon carcinogenesis |
| Grantee: | Gabriela Silva Bisson |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/11002-9 - Jacalin activity in colon carcinogenesis |
| Grantee: | Patricia Modiano |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |