| Full text | |
| Author(s): Show less - |
Coutinho, Fernanda
;
Guimaraes, Lara M. F.
;
Seeger, Rodrigo
;
Santos, Ana Paula J.
;
Glaser, Talita
;
Yamamoto, Denise
;
Lacerda, Lucas
;
Arnaud-Sampaio, Vanessa
;
Rossini, Caio V. T.
;
Rabelo, Izadora
;
de Medeiros, Nathalia Miranda
;
Truzzi, Daniela Ramos
;
Juliano, Maria Aparecida
;
Juliano, Luiz
;
Ulrich, Henning
;
Lameu, Claudiana
Total Authors: 16
|
| Document type: | Journal article |
| Source: | Toxicon; v. 233, p. 9-pg., 2023-09-01. |
| Abstract | |
Cancer is a global public health issue. Neuroblastoma (NB) originates from any tissue of the sympathetic nervous system, and the most affected site is the abdomen. The adrenal gland is the primary site in 38% of cases. Approximately 50% of patients have metastatic disease at diagnosis, and bone marrow is often affected. Meta-static disease is characterized by the spreading of cancer cells that are frequently resistant to chemotherapy and radiotherapy from the primary tumor to other specific parts of the body and is responsible for 90% of cancer-related deaths. Increasing evidence has indicated that nitric oxide (NO) signaling is implicated in the patho-physiology of many types of cancer, particularly in tumorigenesis and cancer progression. However, the effect of NO on metastasis cannot be easily classified as prometastatic or antimetastatic. An understanding at the mo-lecular level of the role of NO in cancer will have profound therapeutic implications for the diagnosis and treatment of disease. Here, the proline-rich decapeptide isolated from Bothrops jararaca venom (Bj-PRO-10c) that enhances and sustains the generation of NO was used to unravel the role of metabolic NO in steps of metastasis. Bj-PRO-10c showed an antimetastatic effect, mainly by interfering with actin cytoskeleton rearrangement, controlling cell proliferation, and decreasing the seeding efficiency of NB in metastatic niches. Therefore, we proposed that an approach for controlled NO induction with the right molecular strategies can hopefully inhibit metastasis and increase the lifespan of NB patients. (AU) | |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 16/11098-0 - The nitric oxide influence on neuroblastoma metastasis in the bone marrow |
| Grantee: | Fernanda Cardoso Coutinho |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 18/18799-9 - Effect of Bj-PRO-10c on exosomal miRNA expression: role in cancer cachexia and neuroblastoma metastasis |
| Grantee: | Fernanda Cardoso Coutinho |
| Support Opportunities: | Scholarships abroad - Research Internship - Scientific Initiation |
| FAPESP's process: | 19/17483-0 - Dinitrosyl iron complexes (DNICs): formation, reactivity, and implications for the physiopathology of nitric oxide |
| Grantee: | Daniela Ramos Truzzi |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/19128-2 - Metastasis mechanisms of childhood tumors to bone marrow |
| Grantee: | Claudiana Lameu |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 22/11093-9 - Purinergic signaling in the phenotypic transition of Tumor Associated Macrophages (TAMs) and Circulating Tumor Cells (CTCs) to Breast Cancer brain metastasis |
| Grantee: | Claudiana Lameu |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/08999-3 - Evaluation of the efficacy of Bj-PRO-10c in the prevention and treatment of cachexia induced by Pancreatic Cancer |
| Grantee: | Caio Vinícius Teles Rossini |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Research Projects - Thematic Grants |