Evaluating the relationship between the type of rescue medication and the adequacy of asthma maintenance therapy

Author(s)

Ponte, Eduardo Vieira ; da Rocha, Daniel Gimenez ; Guinossi, Raissa Martins ; Bertoche, Lais ; Bertolino, Jessica Regina ; Belleze, Leticia ; Galastri, Ana Lucia Bergamasco ; Mamoni, Ronei Luciano

• Document type: Journal article
• Source: RESPIRATORY MEDICINE; v. 217, p. 5-pg., 2023-10-01.

Abstract

Introduction: Current guidelines incorporate the option of a rapid onset bronchodilator (ROB) plus an inhaled corticosteroid (ICS) for the relief of asthma symptoms, but there is doubt whether the combined therapy for relief could lead to suboptimal maintenance therapy since individuals might prefer it to the maintenance therapy. The objective of this study was to assess whether the type of rescue medication that the individual with asthma has available is associated with suboptimal maintenance therapy. Methods: This cross-sectional study included non-smokers with asthma, & GE;12 years old. The individuals attended an appointment with a physician, responded questionnaires and performed a spirometry. Adjusted regression analysis evaluated whether the type of rescue medication was associated with suboptimal maintenance therapy. Results: We enrolled 953 individuals, of which 221 reported having no rescue medication, 171 carried any ROB + ICS for symptoms relief and 561 carried SABA alone to rescue. The frequency of suboptimal maintenance therapy was not different between individuals carrying the combination and those carrying SABA alone for symptoms relief, but individuals who reported having no rescue medication had less suboptimal maintenance therapy (P < 0.01). Conclusions: The frequency of suboptimal maintenance therapy for asthma was similar between individuals carrying any ROB + ICS for symptoms relief and those carrying SABA alone to rescue, whilst it was less frequent in the group that reported not having any reliever medication. Data from this study indicate that recent changes in asthma guidelines regarding the use of rescue medication have little risk of impairing maintenance therapy. (AU)

• FAPESP's process: 17/18367-9 - RISK FACTORS FOR RAPID LOSS OF LUNG FUNCTION, IRREVERSIBLE AIRWAY OBSTRUCTION AND REFRACTORY DISEASE IN SUBJECTS WITH ASTHMA
• Grantee: Eduardo Vieira Ponte
• Support Opportunities: Regular Research Grants