Recent advances in electrochemical nanomaterial-based aptasensors for the detection of cancer biomarkers

Author(s)

Negahdary, Masoud ; Angnes, Lucio

• Document type: Journal article
• Source: Talanta; v. 259, p. 24-pg., 2023-04-14.

Abstract

New technologies have provided suitable tools for rapid diagnosis of cancer which can reduce treatment costs and even increase patients' survival rates. Recently, the development of electrochemical aptamer-based nanobiosensors has raised great hopes for early, sensitive, selective, and low-cost cancer diagnosis. Here, we reviewed the flagged recent research (2021-2023) developed as a series of biosensors equipped with nanomaterials and aptamer sequences (nanoaptasensors) to diagnose/prognosis of various types of cancers. Equipping these aptasensors with nanomaterials and using advanced biomolecular technologies have provided specified biosensing interfaces for more optimal and reliable detection of cancer biomarkers. The primary intention of this review was to present and categorize the latest innovations used in the design of these diagnostic tools, including the hottest surface modifications and assembly of sensing bioplatforms considering diagnostic mechanisms. The main classification is based on applying various nanomaterials and sub-classifications considered based on the type of analyte and other vital features. This review may help design subsequent electrochemical aptasensors. Likewise, the up-to-date status, remaining limitations, and possible paths for translating aptasensors to clinical cancer assay tools can be clarified. (AU)

• FAPESP's process: 19/27021-4 - Design and fabrication of electrochemical biosensors for early diagnosis of myocardial infarction and Hepatocellular Carcinoma using microRNAs (miRNAs) primers as biorecognition element and arrays of gold nanostructures
• Grantee: Masoud Negahdary
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/13137-5 - Formation and properties of hemiesters of carbonic acid in aqueous medium
• Grantee: Claudimir Lucio Do Lago
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants