| Full text | |
| Author(s): Show less - |
Glaser, Talita
;
Andrejew, Roberta
;
Oliveira-Giacomelli, Agatha
;
Ribeiro, Deidiane Elisa
;
Marques, Lucas Bonfim
;
Ye, Qing
;
Ren, Wen-Jing
;
Semyanov, Alexey
;
Illes, Peter
;
Tang, Yong
;
Ulrich, Henning
Total Authors: 11
|
| Document type: | Journal article |
| Source: | NEUROSCIENCE BULLETIN; v. 36, n. 11, p. 16-pg., 2020-10-07. |
| Abstract | |
Huntington's (HD) and Parkinson's diseases (PD) are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms, respectively. We review here the participation of purinergic receptors through intracellular Ca(2+)signaling in these neurodegenerative diseases. The adenosine A(2A)receptor stimulates striatopallidal GABAergic neurons, resulting in inhibitory actions on GABAergic neurons of the globus pallidus. A(2A)and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition, and A(2A)receptor activation results in motor inhibition. Furthermore, the A(2A)receptor physically and functionally interacts with glutamate receptors, mainly with the mGlu5 receptor subtype. This interaction facilitates glutamate release, resulting in NMDA glutamate receptor activation and an increase of Ca(2+)influx. P2X7 receptor activation also promotes glutamate release and neuronal damage. Thus, modulation of purinergic receptor activity, such as A(2A)and P2X7 receptors, and subsequent aberrant Ca(2+)signaling, might present interesting therapeutic potential for HD and PD. (AU) | |
| FAPESP's process: | 18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease |
| Grantee: | Deidiane Elisa Ribeiro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease |
| Grantee: | Roberta Andrejew Caetano |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision |
| Grantee: | Talita Glaser |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease |
| Grantee: | Ágatha Oliveira Giacomelli |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Research Projects - Thematic Grants |