Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Author(s)

Gusmao, Luiza Araujo ; Matsuo, Flavia Sayuri ; Barbosa, Hellen Franciane Goncalves ; Tedesco, Antonio Claudio

• Document type: Journal article
• Source: FRONTIERS IN NANOTECHNOLOGY; v. 4, p. 14-pg., 2022-08-31.

Abstract

The development of nano-based materials for diagnosis enables a more precise prognosis and results. Inorganic, organic, or hybrid nanoparticles using nanomaterials, such as quantum dots, extracellular vesicle systems, and others, with different molecular compositions, have been extensively explored as a better strategy to overcome the blood-brain barrier and target brain tissue and tumors. Glioblastoma multiforme (GBM) is the most common and aggressive primary tumor of the central nervous system, with a short, established prognosis. The delay in early detection is considered a key challenge in designing a precise and efficient treatment with the most encouraging prognosis. Therefore, the present mini-review focuses on discussing distinct strategies presented recently in the literature regarding nanostructures' use, design, and application for GBM diagnosis. (AU)

• FAPESP's process: 13/50181-1 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders
• Grantee: Antonio Claudio Tedesco
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/17911-0 - Lipid nanocarrier covered with polymer applied to the diagnosis and treatment of pathologies from central nervous system by intranasal delivery of therapeutic agents
• Grantee: Hellen Franciane Gonçalves Barbosa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral