Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial

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Cle, Diego, V ; Catto, Luiz Fernando B. ; Gutierrez-Rodrigues, Fernanda ; Donaires, Flavia S. ; Pinto, Andre L. ; Santana, Barbara A. ; Darrigo Jr, Luiz Guilherme ; Valera, Elvis T. ; Koenigkam-Santos, Marcel ; Baddini-Martinez, Jose ; Young, Neal S. ; Martinez, Edson Z. ; Calado, Rodrigo T.

• Document type: Journal article
• Source: Haematologica; v. 108, n. 5, p. 13-pg., 2023-05-01.

Abstract

Androgens have been reported to elongate telomeres in retrospective and prospective trials with patients with telomeropathies, mainly with bone marrow failure. In our single-arm prospective clinical trial (clinicaltrials gov. Identifier: NCT02055456), 17 patients with short telomeres and/or germline pathogenic variants in telomere biology genes associated with at least one cytopenia and/or radiologic diagnosis of interstitial lung disease were treated with 5 mg/kg of intramuscular nandrolone decanoate every 15 days for 2 years. Ten of 13 evaluable patients (77%) showed telomere elongation at 12 months by flow-fluorescence in situ hybridization (average increase, 0.87 kb; 95% confidence interval: 0.20-1.55 kb; P=0.01). At 24 months, all ten evaluable patients showed telomere elongation (average increase, 0.49 kb; 95% confidence interval: 0.24-1.23 kb; P=0.18). Hematologic response was achieved in eight of 16 patients (50%) with marrow failure at 12 months, and in ten of 16 patients (63%) at 24 months. Seven patients had interstitial lung disease at baseline, and two and three had pulmonary response at 12 and 24 months, respectively. Two patients died due to pulmonary failure during treatment. In the remaining evaluable patients, the pulmonary function remained stable or improved, but showed consistent decline after cessation of treatment. Somatic mutations in myeloid neoplasm-related genes were present in a minority of patients and were mostly stable during drug treatment. The most common adverse events were elevations in liver function test levels in 88%, acne in 59%, and virilization in 59%. No adverse events grade >= 4 was observed. Our findings indicate that nandrolone decanoate elongates telomeres in patients with telomeropathies, which correlated with clinical improvement in some cases and tolerable adverse events. (AU)

• FAPESP's process: 16/12799-1 - Correlation between genotype, and telomere length, and phenotype in telomeropathies
• Grantee: Rodrigo do Tocantins Calado de Saloma Rodrigues
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC