| Full text | |
| Author(s): Show less - |
Kwon, Nahyun
;
Jasinevicius, Gabriel O.
;
Kassab, Giulia
;
Ding, Lili
;
Bu, Jiachuan
;
Martinelli, Leticia P.
;
Ferreira, Vinicius G.
;
Dhaliwal, Alexander
;
Chan, Harley H. L.
;
Mo, Yulin
;
Bagnato, Vanderlei S.
;
Kurachi, Cristina
;
Chen, Juan
;
Zheng, Gang
;
Buzza, Hilde H.
Total Authors: 15
|
| Document type: | Journal article |
| Source: | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION; v. N/A, p. 12-pg., 2023-05-31. |
| Abstract | |
Indocyanine green (ICG) is the only near-infrared (NIR) dye approved for clinical use. Despite its versatility in photonic applications and potential for photothermal therapy, its photobleaching hinders its application. Here we discovered a nanostructure of dimeric ICG (Nano-dICG) generated by using ICG to stabilize nanoemulsions, after which ICG enabled complete dimerization on the nanoemulsion shell, followed by J-aggregation of ICG-dimer, resulting in a narrow, red-shifted (780 nm -> 894 nm) and intense (approximate to 2-fold) absorbance. Compared to ICG, Nano-dICG demonstrated superior photothermal conversion (2-fold higher), significantly reduced photodegradation (-9.6 % vs. -46.3 %), and undiminished photothermal effect (7 vs. 2 cycles) under repeated irradiations, in addition to excellent colloidal and structural stabilities. Following intravenous injection, Nano-dICG enabled real-time tracking of its delivery to mouse tumors within 24 h by photoacoustic imaging at NIR wavelength (890 nm) distinct from the endogenous signal to guide effective photothermal therapy. The unprecedented finding of nanostructure-driven ICG dimerization leads to an ultra-stable phototheranostic platform. (AU) | |
| FAPESP's process: | 16/14033-6 - Basic studies of the combination of photothermal and photodynamic effects in application of a new modality for the Cancer treatment |
| Grantee: | Hilde Harb Buzzá |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Projects - Thematic Grants |