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Basic studies of the combination of photothermal and photodynamic effects in application of a new modality for the Cancer treatment

Grant number: 16/14033-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2017
Effective date (End): May 21, 2020
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Vanderlei Salvador Bagnato
Grantee:Hilde Harb Buzzá
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:13/07276-1 - CEPOF - Optics and Photonic Research Center, AP.CEPID
Associated scholarship(s):17/26710-5 - Studies of porphysomes and J-aggregates and the understanding of light and heat distribuiton to apply in photothermal therapy for tumor treatment, BE.EP.PD

Abstract

Cancer is the name for more than a hundred types of diseases that have in common the loss of cell differentiation ability and uncontrolled growth of cells, resulting in the formation of neoplasia such as tumors. In some cases, the options available for treatment of Cancer are considered inefficient and are discarded because of several side effects, showing a need for the discovery of new therapeutic solutions. The photonic alternative therapies are highly visible since they are located and have reducing side effects. Photodynamic Therapy (PDT) is based in the interaction among light, a photosensitive agent and the molecular oxygen, which results in the death of the target cell. Despite its wide application, there are few studies about the effects of temperature on the PDT mechanisms. Photothermia is the technique that uses light to increase the temperature of a region to treat, e.g., Cancers and the increased thermal effect can be obtained by introducing nanoparticles into the tumor region. The objective of this project is to understand the synergistic effect of the combination of these two therapies, which use light as a fundamental element. For this, two types of nanoparticles will be synthesized with effective heat production when irradiated, and also a photosensitizer molecule will be added. With the production of these nanoparticles, in vitro studies will be performed in vivo and in ovo to increase the understanding of the mechanisms of heat production in normal and tumor tissue besides the analysis of the efficacy of the photodynamic and photothermal therapies, individually. Understanding their individual effects, this project proposes a new therapeutic modality using a combination of both for the treatment of Cancer. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUZZA, HILDE H.; ZANGIROLAMI, AMANDA C.; KURACHI, CRISTINA; BAGNATO, VANDERLEI S. Acceleration of newborn rats' development with the use of photobiomodulation and the near possibility of application in human premature babies. Journal of Biophotonics, v. 12, n. 8 AUG 2019. Web of Science Citations: 0.
BUZZA, HILDE HARB; FIALHO DE FREITAS, LUCAS CRUZ; MORIYAMA, LILIAN TAN; TEIXEIRA ROSA, RAMON GABRIEL; BAGNATO, VANDERLEI SALVADOR; KURACHI, CRISTINA. Vascular Effects of Photodynamic Therapy with Curcumin in a Chorioallantoic Membrane Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 5 MAR 1 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.