| Full text | |
| Author(s): |
Tanaka, Denise Mayumi
;
Simoes, Marcus Vinicius
;
Marin-Neto, Jose Antonio
Total Authors: 3
|
| Document type: | Journal article |
| Source: | EXPERT REVIEW OF CARDIOVASCULAR THERAPY; v. 21, n. 6, p. 9-pg., 2023-05-25. |
| Abstract | |
Introduction: Myocardial ischemia is common in patients with chronic Chagas cardiomyopathy (CCC), but only recently clinical and experimental studies highlighted the involvement of this abnormality as contributing to the progression of myocardial damage. Areas covered: Despite the absence of obstructive epicardial coronary artery disease at angiography, and limited evidence of abnormal flow regulation at the macrovascular level, remarkable functional and structural microvascular abnormalities are consistently reported by independent investigations of CCC. These derangements occur early and contribute to myocardial dysfunction. Recent research focused on reversing microvascular dysfunction as a target to positively impact the course of CCC. We conducted an extensive review of the scientific literature, aiming to summarize the role of coronary dysfunction causing myocardial ischemia in CCC, with a focus on implications for clinical management of individuals affected by this disease. Expert Opinion: Preclinical studies showed a clear correlation between perfusion defects and inflammation in viable but impaired dysfunctional myocardium. These findings provided further insight into the CCC complex pathophysiology and support the role of very few recent therapeutic interventions aiming to relieve myocardial ischemia. Further research is warranted to assess the efficacy of new interventions addressing reversal of microvascular ischemia and inflammation modulation and halting ventricular dysfunction progression in CCC. (AU) | |
| FAPESP's process: | 17/16450-6 - EFFECTS OF PROLONGED USE OF PENTOXIFILINE OVER MYOCARDIAL PERFUSION CHANGES, ARRYTHMIA EVENTS AND LEFT VENTRICULAR DYSFUNCTION IN THE CHRONIC CHAGAS CARDIOMYOPATHY |
| Grantee: | Marcus Vinicius Simões |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/25403-9 - Investigations on the pathogenesis, pathophysiology and therapy in humans and in an experimental model with the chronic cardiomyopathy of Chagas Disease |
| Grantee: | José Antonio Marin-Neto |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/21250-1 - Chronic Chagas Cardiomyopathy in experimental animal model: prospective study of anatomic and functional ventricular changes and the effect of therapeutic interventions |
| Grantee: | Denise Mayumi Tanaka |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |