Co-infection of Leishmania infantum and a Crithidia- related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

Author(s):Show less -

Rogerio, Luana Aparecida ; Takahashi, Talita Yuri ; Cardoso, Luria ; Takamiya, Nayore Tamie ; de Melo, Enaldo Vieira ; de Jesus, Amelia Ribeiro ; de Oliveira, Fabricia Alvisi ; Forrester, Sarah ; Jeffares, Daniel C. ; Ribeiro, Jose Marcos ; Almeida, Roque Pacheco ; Maruyama, Sandra Regina ; da Silva, Joao Santana

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES; v. 133, p. 4-pg., 2023-05-30.

Abstract

We report a refractory and relapsed visceral leishmaniasis case in a male child patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at the genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia -related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) (AU)

• FAPESP's process: 21/12464-8 - Developing molecular tools for the study of emerging parasites in Visceral Leishmaniasis
• Grantee: Nayore Tamie Takamiya
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/03095-9 - Screening of clinical isolates of Leishmania sp. for genome sequencing
• Grantee: Talita Yuri Takahashi
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/12142-0 - Structural genomic analysis of two clinical isolates from a fatal case of visceral leishmaniasis
• Grantee: Talita Yuri Takahashi
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 16/20258-0 - Visceral leishmaniasis: genomics approaches for integrated molecular analysis of host and parasite
• Grantee: Sandra Regina Costa Maruyama
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/14011-8 - Phenotypic characterization and genomic analysis of Crithidia-like parasites obtained from patients diagnosed with Visceral Leishmaniasis
• Grantee: Luana Aparecida Rogerio
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/16328-6 - Visceral Leishmaniasis: genomics approaches for integrated molecular analysis of host and parasite.
• Grantee: Sandra Regina Costa Maruyama
• Support Opportunities: Scholarships in Brazil - Young Researchers