Impact of vitamin D supplementation on modulating heat-shock proteins in postmenopausal women: a randomized, double-blind, placebo-controlled study

Author(s)

Orsatti, Claudio Lera ; Orsatti, Fabio Lera ; de Souza, Joao Pedro Esteves Alves ; Nahas, Eliana Aguiar Petri

• Document type: Journal article
• Source: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 30, n. 7, p. 8-pg., 2023-07-01.

Abstract

ObjectiveThe aim of this study was to examine the effect of vitamin D (VitD) supplementation on serum heat-shock proteins (HSP) in postmenopausal women (PW).MethodsIn this double-blind, placebo-controlled trial, 160 PW aged 45 to 65 years with amenorrhea 12 months or more were randomized into two groups: 80 PW in VitD group (oral supplementation with 1,000 IU VitD(3)/d) or 80 PW in placebo group. The PW were assessed at baseline and after 10 months of intervention. Plasma concentrations of 25-hydroxyVitD (25[OH]D) were measured by high-performance liquid chromatography. HSP27/pS78/pS82, HSP27/total, HSP60, HSP70/72, and HSP90 & alpha; levels were assessed in serum using a multiplexed bead immunoassay.ResultsHSP27 (pS78/pS82 [P < 0.035] and total [P < 0.001]) levels increased in the supplemented group when compared with the control group. There was no effect of VitD supplementation on HSP60, HSP70/72, and HSP90 & alpha; levels.ConclusionsVitamin D supplementation increases serum HSP27 level in PW. (AU)

• FAPESP's process: 14/19382-3 - The role of vitamin D on cardiometabolic and immuno-inflammatory profile of postmenopausal women
• Grantee: Eliana Aguiar Petri Nahás
• Support Opportunities: Regular Research Grants