Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study

Author(s)

Tebar, W. R. ; Santos, I. S. ; Meneghini, V. ; Bittencourt, M. S. ; Lotufo, P. A. ; Bensenor, I. M.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 56, n. 1, p. 11-pg., 2023-01-01.

Abstract

The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (ACIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Data from 7564 participants were analyzed (median age of 50.0 [44.0-57.0] years, 56.9% women). CIMT was assessed by ultrasound and ACIMT was calculated by subtracting baseline values from follow-up values. Psoriasis participants were identified by self-reported medical diagnosis (n=143) and compared with matched participants without disease (n=572) and with the entire sample without psoriasis (n=7421). Baseline CIMT explained the 8-year CIMT increase only in 36.9% among psoriasis participants and in B43.0% in participants without disease. CIMT was associated with age (6=0.002, P=0.002) and hypertension (6=0.029, P=0.034) in psoriasis participants. Among participants without psoriasis, CIMT was associated with age, male sex, low educational attainment, past smoking, obesity, diabetes, hypertension, and dyslipidemia (P<0.05). There was an inverse association of CIMT with private health insurance (6=-0.004, P=0.042) and White ethnicity (6=-0.006, P=0.004) in the entire sample without psoriasis but not in matched participants. Psoriasis participants showed an inverse association between ACIMT and diabetes (6=-0.214, P=0.011), while the entire sample without psoriasis showed an inverse association between ACIMT and age (6=-0.005, P<0.001), past smoking (6=-0.048, P=0.009), and hypertension (6=-0.048, P=0.009). In conclusion, psoriasis was not associated with CIMT after an 8-year follow-up. The inverse association of ACIMT with diabetes in psoriasis participants needs further clarification. (AU)

• FAPESP's process: 19/23734-6 - Chronic inflammatory diseases and all-cause, cardiovascular and mortality related to other causes: association with risk factors, subclinical Atherosclerosis and fatal and non-fatal events in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
• Grantee: Isabela Judith Martins Bensenor
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/04416-3 - Association of Lupus, Sjogren, Vasculitis, Celiac Disease and Psoriasis with CAC at baseline and incidence/progression CAC, all-cause and CDV mortality in the 8-year follow-up of ELSA-Brasil
• Grantee: William Rodrigues Tebar
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06798-0 - Autoimmune thyroid disease and inflammatory diseases: association with subclinical Atherosclerosis and general and cardiovascular mortality in ELSA-Brasil
• Grantee: Vandrize Meneghini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral