Progression of subclinical Atherosclerosis markers and a priori eating patterns: an analysis to the longitudinal study in adult health (ELSA-Brazil)

• Grant number: 19/13424-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2019
• End date: March 31, 2024
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Dirce Maria Lobo Marchioni
• Grantee: Leandro Teixeira Cacau
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 20/12326-1 - Association between an index based on planetary health diet and cardiovascular risk outcomes: analysis of epidemiological studies, BE.EP.DD

Abstract

The evaluation of Cardiovascular Disease Risk Markers (CVDs) is a tool in the identification of asymptomatic atherosclerotic processes. Coronary Artery Calcium score (CAC) and carotid intima-media thickness (EMIC) are tests used to determine the presence of subclinical Atherosclerosis. One of the risk factors associated with CVD is diet, and therefore, ways of assessing diet quality are important in understanding its role in the development of this clinical condition. The objective of this project is to investigate the association between a priori eating patterns in the population participating in the Longitudinal Study in Adult Health (ELSA-Brazil) and the progression of markers of subclinical Atherosclerosis. ELSA-Brazil is a multicenter cohort study conducted in more than 15,000 employees aged 35-74 years of 6 public institutions distributed in 3 regions of the country. Socio-demographic, food consumption data obtained by food frequency questionnaire will be used in the first wave of the study and the results of CAC exams in the first and second wave and EMI in the first wave. Food consumption data will be evaluated through the Health Eating Index - 2015 and two indexes that will be developed and validated based on the American Heart Association's planetary diet and metrics. The relationship between a priori eating patterns and EMIC will be evaluated in a cross-sectional study, with data from the first wave of all participants. The progression of subclinical Atherosclerosis verified by CAC will be evaluated longitudinally, using the data of the first and second waves in the Center of São Paulo. The association hypothesis will be tested by multiple regression models. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEVY, JESSICA; SILVA, ALEXSANDRO MACEDO; DE CARLI, EDUARDO; CACAU, LEANDRO TEIXEIRA; DE ALVARENGA, JOSE FERNANDO RINALDI; FIAMONCINI, JARLEI; BENSENOR, ISABELA MARTINS; LOTUFO, PAULO ANDRADE; MARCHIONI, DIRCE MARIA. Biomarkers of Fruit Intake Using a Targeted Metabolomics Approach: an Observational Cross-Sectional Analysis of the ELSA-Brasil Study. Journal of Nutrition, v. 152, n. 9, p. 8-pg., 2022-05-31. (16/20054-6, 18/08319-0, 19/13424-0, 19/11324-8)

CACAU, LEANDRO TEIXEIRA; BENSENOR, ISABELA MARTINS; GOULART, ALESSANDRA CARVALHO; CARDOSO, LETICIA OLIVEIRA; LOTUFO, PAULO ANDRADE; MORENO, LUIS A.; MARCHIONI, DIRCE MARIA. Adherence to the Planetary Health Diet Index and Obesity Indicators in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). NUTRIENTS, v. 13, n. 11, NOV 2021. (11/12256-4, 19/13424-0, 20/12326-1)

CACAU, LEANDRO TEIXEIRA; DE CARLI, EDUARDO; DE CARVALHO, ALINE MARTINS; LOTUFO, PAULO ANDRADE; MORENO, LUIS A.; BENSENOR, ISABELA MARTINS; MARCHIONI, DIRCE MARIA. Development and Validation of an Index Based on EAT-Lancet Recommendations: The Planetary Health Diet Index. NUTRIENTS, v. 13, n. 5, MAY 2021. (11/12256-4, 19/13424-0)

CACAU, LEANDRO TEIXEIRA; MARCADENTI, ALINE; BERSCH-FERREIRA, ANGELA CRISTINE; WEBER, BERNARDETE; ALMEIDA, JUSSARA CARNEVALE DE; RODRIGUES, CINTIA CORTE REAL; LOTUFO, PAULO ANDRADE; BENSENOR, ISABELA MARTINS; MARCHIONI, DIRCE MARIA. The AHA Recommendations for a Healthy Diet and Ultra-Processed Foods: Building a New Diet Quality Index. FRONTIERS IN NUTRITION, v. 9, p. 8-pg., 2022-04-11. (11/12256-4, 19/13424-0)

ALVES, MARIANE DE A.; MIRANDA, ANDREIA M.; CACAU, LEANDRO T.; LEVY, JESSICA; GENEROSO, GIULIANO; BITTENCOURT, MARCIO S.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; MARCHIONI, DIRCE M.. Dietary patterns and subclinical atherosclerosis incidence and progression: Results from ELSA-Brasil. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 33, n. 1, p. 9-pg., 2023-01-01. (19/13486-5, 11/12256-4, 19/13424-0)

MARCHIONI, DIRCE MARIA; CACAU, LEANDRO TEIXEIRA; DE CARLI, EDUARDO; DE CARVALHO, ALINE MARTINS; RULLI, MARIA CRISTINA. Low Adherence to the EAT-Lancet Sustainable Reference Diet in the Brazilian Population: Findings from the National Dietary Survey 2017-2018. NUTRIENTS, v. 14, n. 6, p. 14-pg., 2022-03-01. (20/12326-1, 19/13424-0)

CACAU, LEANDRO TEIXEIRA; LEVY, JESSICA; ALVES, MARIANE DE ALMEIDA; SANTOS, ITAMAR DE SOUZA; FONSECA, MARIA DE JESUS MENDES; LOTUFO, PAULO ANDRADE; BENSENOR, ISABELA MARTINS; MARCHIONI, DIRCE MARIA. Association between dietary patterns and carotid intima-media thickness: cross-sectional analysis of ELSA-Brasil study. EUROPEAN JOURNAL OF NUTRITION, v. N/A, p. 11-pg., 2023-02-02. (11/12256-4, 18/08319-0, 19/13424-0, 19/13486-5)

CACAU, LEANDRO TEIXEIRA; BENSENOR, ISABELA MARTINS; GOULART, ALESSANDRA CARVALHO; CARDOSO, LETICIA DE OLIVEIRA; SANTOS, ITAMAR DE SOUZA; LOTUFO, PAULO ANDRADE; MORENO, LUIS A.; MARCHIONI, DIRCE MARIA. Adherence to the EAT-Lancet sustainable reference diet and cardiometabolic risk profile: cross-sectional results from the ELSA-Brasil cohort study. EUROPEAN JOURNAL OF NUTRITION, v. 62, n. 2, p. 11-pg., 2022-10-21. (20/12326-1, 11/12256-4, 19/13424-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CACAU, Leandro Teixeira. Indices for evaluating sustainable and cardiovascular health-promoting diets: development, validation, and application. 2024. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.