Progression of subclinical Atherosclerosis markers and a priori eating patterns: an analysis to the longitudinal study in adult health (ELSA-Brazil)

• Grant number: 19/13424-0
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): September 01, 2019
• Effective date (End): March 31, 2023
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Dirce Maria Lobo Marchioni
• Grantee: Leandro Teixeira Cacau
• Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The evaluation of Cardiovascular Disease Risk Markers (CVDs) is a tool in the identification of asymptomatic atherosclerotic processes. Coronary Artery Calcium score (CAC) and carotid intima-media thickness (EMIC) are tests used to determine the presence of subclinical Atherosclerosis. One of the risk factors associated with CVD is diet, and therefore, ways of assessing diet quality are important in understanding its role in the development of this clinical condition. The objective of this project is to investigate the association between a priori eating patterns in the population participating in the Longitudinal Study in Adult Health (ELSA-Brazil) and the progression of markers of subclinical Atherosclerosis. ELSA-Brazil is a multicenter cohort study conducted in more than 15,000 employees aged 35-74 years of 6 public institutions distributed in 3 regions of the country. Socio-demographic, food consumption data obtained by food frequency questionnaire will be used in the first wave of the study and the results of CAC exams in the first and second wave and EMI in the first wave. Food consumption data will be evaluated through the Health Eating Index - 2015 and two indexes that will be developed and validated based on the American Heart Association's planetary diet and metrics. The relationship between a priori eating patterns and EMIC will be evaluated in a cross-sectional study, with data from the first wave of all participants. The progression of subclinical Atherosclerosis verified by CAC will be evaluated longitudinally, using the data of the first and second waves in the Center of São Paulo. The association hypothesis will be tested by multiple regression models. (AU)