Severe acute respiratory syndrome by influenza and factors associated with death in older adults: a population study

Author(s)

Goncalves, Thayna Martins ; Shimabukuro, Patricia Mitsue Saruhashi ; Hiraki, Karen Renata Nakamura ; Braz-Silva, Paulo Henrique ; Giannecchini, Simone ; To, Kelvin Kai-Wang ; Taminato, Monica ; de Morais, Richarlisson Borges

• Document type: Journal article
• Source: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES; v. 17, n. 2, p. 10-pg., 2023-02-01.

Abstract

Introduction: Influenza is characterized by an acute viral infection, which can lead to severe conditions and death, especially in vulnerable populations, such as older adults. Therefore, we sought to analyze cases of severe acute respiratory syndrome (SARS) due to influenza in older adults registered in Brazil and investigate the factors related to death due to this disease.Methodology: This is a cross-sectional, population-based study that used secondary data from the Influenza Epidemiological Surveillance Information System (IESIS-Influenza). Older adults aged 60 years and above with laboratory diagnosis of influenza were included.Results: A total of 3,547 older adults with SARS due to influenza were included, out of which 1,185 cases with death as the outcome were identified. Among older adults with death as the outcome, 87.4% were not vaccinated against influenza. The main risk factors for death were invasive ventilatory support use, intensive care unit admission, brown skin color and dyspnea (p < 0.001).Conclusions: This study described the profile of older adults with SARS due to influenza in Brazil. Factors associated with death in this population were identified. Moreover, the need to encourage compliance with vaccination among older adults is evident in order to prevent severe cases and unfavorable outcomes related to influenza. (AU)

• FAPESP's process: 21/04492-1 - Serological survey for SARS-CoV-2 and viral detection in children with chronic kidney disease in renal replacement therapy and kidney transplantation
• Grantee: Mônica Taminato
• Support Opportunities: Regular Research Grants