Graphite-polyurethane composite electrode modified with nickel(II) nanoparticles submitted to electrochemical pretreatment in basic medium for the determination of atenolol

Author(s)

de Arruda Silva, Joao Vitor ; Cavalheiro, Eder T. G. ; Cervini, Priscila

• Document type: Journal article
• Source: Analytical Letters; v. N/A, p. 16-pg., 2023-04-19.

Abstract

A new approach for the determination of atenolol (ATN) at a graphite polyurethane composite electrode (GPUE) modified with electrodeposited nickel(II) nanoparticles electrochemically pretreated in alkaline medium (GPUE-NiNP) is reported. The electrodeposition of NiNP on the GPUE surface was performed by 5 scans in cyclic voltammetry between 0.0 to -1.5 V (vs. SCE) and scan rate of 20 mV s(-1) in a 0.05 mol L-1 NiSO4 and 0.32 mol L-1 H3BO3 solution at pH 5. After deposition, the GPUE-NiNP was submitted to an electrochemical pretreatment in 0.50 mol L-1 NaOH by cyclic voltammetry at 100 mV s(-1). The best results were obtained after 50 cycles at 100 mV s(-1). Quantitative measurements at GPUE-NiNP were performed using differential pulse voltammetry (DPV) in pH 11 universal buffer. Atenolol promotes a decrease in the nickel oxide signals probably due to a complexation of the analyte with free Ni2+ in solution. Thus, the analyte was quantified by the signal suppression and an analytical curve was obtained at the GPUE-NiNP using the optimized conditions for 1.0 to 100 x 10(-8 )mol L-1 atenolol between 1.0 and 0.0 V (vs. SCE) with a linear range between 2.0 x 10(-8) and 1.0 x 10(-7 )mol L-1 and a limit of detection of 3.47 x 10(-9 )mol L-1 with R = 0.9995 for GPUE-NiNP. The procedure was applied to three commercial pharmaceutical formulations with recoveries between 99.5 and 100.7% and agreed with a comparative HPLC procedure within 95% confidence level according to the Student's t-test. (AU)

• FAPESP's process: 19/22217-8 - Thermoanalytical studies applied to antihepatitis and antiretroviral drugs of the protease inhibitor class: thermal behavior, decomposition intermediates, volatile characterization and polymorphism
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants