Analysis of colon tumors in rats by near-infrared Raman spectroscopy

Author(s)

Duarte, Janaina ; Hage, Raduan ; Silveira, Landulfo, Jr. ; Silveira, Fabricio ; Pacheco, Marcos Tadeu T. ; Munin, Egberto ; Plapler, Helio ; Kessel, D

• Document type: Journal article
• Source: MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS; v. 6427, p. 6-pg., 2007-01-01.

Abstract

Biomedical applications of near-infrared Raman spectroscopy have increased their importance at the last ten years. This technique can determinate the molecular composition of materials, allowing a sensible and fast biological diagnosis. It has showed to be a promising tool for health diagnosis due to its high sensibility. Colorectal cancer (CRC) is one of the most common malignant tumors in humans beings. In the last decades many experimental models have been developed in animals based in the use of chemical composites to induce the formation and development of these tumors, many of them present similar characteristics to those of natural occurrence aiming to the attainment of information on genesis, evolution, as well as diagnosis and more efficient therapies for treating these neoplasias. Amongst the most used chemical composites is the 1,2-dimetilhydrazine (DMH) because its morphological and histological similarity to those tumors. This study aims to compare in vivo normal colon tissue and tumoral colon tissue, induced by DMH, in rats by near-infrared Raman spectroscopy to permit the use in the near future for an efficient diagnosis in real time besides being useful as an auxiliary method for several therapies, including the photodynamic therapy. (AU)

• FAPESP's process: 05/02304-0 - Comparative study of Al (III) phthalocyanine chloride tetrasulfonic acid and phthalocyanine chloride in lipossomal vehicle used in photodynamic therapy in rats colon tumors
• Grantee: Helio Plapler
• Support Opportunities: Regular Research Grants