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Non-Conventional Applications of Computerized Tomography: Analysis of Solid Dosage Forms Produced by Pharmaceutical Industry

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Author(s):
de Oliveira, Jose Martins, Jr. ; Germano Martins, Antonio Cesar ; Deppman, A ; Krug, C ; Zahn, GS ; Lubian, J ; Added, N ; Timoteo, VS
Total Authors: 8
Document type: Journal article
Source: MAGNETIC FIELDS IN THE UNIVERSE: FROM LABORATORY AND STARS TO PRIMORDIAL STRUCTURES; v. 1245, p. 3-pg., 2010-01-01.
Abstract

X-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a nonconventional application of computerized tomography: visualization and improvements in the understanding of some internal structural features of solid dosage forms. A micro-CT X-ray scanner, with a minimum resolution of 30 mu m was used to characterize some pharmaceutical tablets, granules, controlled-release osmotic tablet and liquid-filled soft-gelatin capsules. The analysis presented in this work are essentially qualitative, but quantitative parameters, such as porosity, density distribution, tablets dimensions, etc. could also be obtained using the related CT techniques. (AU)

FAPESP's process: 05/04727-6 - Characterization of materials using computerized tomography by X-ray transmission
Grantee:José Martins de Oliveira Junior
Support Opportunities: Regular Research Grants