Chiral Chalcogen Peptides as Ligands for the Catalytic Enantioselective Aryl Transfer Reaction to Aldehydes

Author(s)

Schwab, Ricardo S. ; Soares, Letiere C. ; Dornelles, Luciano ; Rodrigues, Oscar E. D. ; Paixao, Marcio W. ; Godoi, Marcelo ; Braga, Antonio L.

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2010, n. 19, p. 5-pg., 2010-07-01.

Abstract

A new series of chiral chalcogen peptides were synthesized from inexpensive and commercially available starting materials. The synthesized compounds were tested as catalysts in the enantioselective arylation of aldehydes by using arylboronic acids as the aryl source. The desired diarylmethanols were obtained in excellent yields and with enantioselectivities up to 91% ee. (AU)

• FAPESP's process: 09/14352-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
• Grantee: Márcio Weber Paixão
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
• Grantee: Márcio Weber Paixão
• Support Opportunities: Research Grants - Young Investigators Grants