Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

Advanced search

Search - Use quotation marks to get a more specific result

Index

Field of knowledge

Start date

Betweenand

Full text
Author(s):	Brassesco, Maria Sol ; Xavier, Danilo Jordao ; Camparoto, Marjori Leiva ; Montaldi, Ana Paula ; D'Auria Vieira de Godoy, Paulo Roberto ; Scrideli, Carlos Alberto ; Tone, Luiz Gonzaga ; Sakamoto-Hojo, Elza Tiemi Total Authors: 8
Document type:	Journal article
Source:	JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; v. N/A, p. 8-pg., 2011-01-01.
Abstract
Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort. (AU)