Evaluation of antineoplastic effects of Zebularine on childhood acute lymphoblastic leukemia cell lines.

• Grant number: 10/14378-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: February 29, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Luiz Gonzaga Tone
• Grantee: Augusto Faria Andrade
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood and represents a heterogeneous disease in relation to its biology and prognosis. The treatment is divided into remission induction therapy, intensification or consolidation and maintenance (administration of mercaptopurine and methotrexate). Despite advances in treatment about 20% of patients with disease recurrence and / or death indicating the need for different therapies for this group. Recently, drugs such epigenetic inhibitors of DNA-methyltransferase (iDNMTs) have shown anti-neoplastic and promising results for the treatment of several types of neoplasms including the LLA. Whereas a portion of patients with ALL have a poor response to chemotherapy, this study aims to evaluate the effects of a iDNMT (Zebularine) associated with chemotherapy (mercaptopurine and methotrexate) ALL cell lines, as possible adjuvant therapy to acute lymphoblastic leukemia instead of conventional treatment.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

ANDRADE, AUGUSTO F.; BORGES, KLEITON S.; CASTRO-GAMERO, ANGEL M.; SILVEIRA, VANESSA S.; SUAZO, VERIDIANA K.; OLIVEIRA, JAQUELINE C.; MORENO, DANIEL A.; DE PAULA QUEIROZ, ROSANE G.; SCRIDELI, CARLOS A.; TONE, LUIZ G.. Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells. ANTI-CANCER DRUGS, v. 25, n. 1, p. 72-81, JAN 2014. (10/14378-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ANDRADE, Augusto Faria. Evaluation of Antineoplastic Effects of Zebularine on Childhood Acute Lymphoblastic Leukemia Cell Lines.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.