| Grant number: | 10/14378-7 |
| Support type: | Scholarships in Brazil - Master |
| Effective date (Start): | March 01, 2011 |
| Effective date (End): | February 29, 2012 |
| Field of knowledge: | Health Sciences - Medicine - Maternal and Child Health |
| Principal Investigator: | Luiz Gonzaga Tone |
| Grantee: | Augusto Faria Andrade |
| Home Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood and represents a heterogeneous disease in relation to its biology and prognosis. The treatment is divided into remission induction therapy, intensification or consolidation and maintenance (administration of mercaptopurine and methotrexate). Despite advances in treatment about 20% of patients with disease recurrence and / or death indicating the need for different therapies for this group. Recently, drugs such epigenetic inhibitors of DNA-methyltransferase (iDNMTs) have shown anti-neoplastic and promising results for the treatment of several types of neoplasms including the LLA. Whereas a portion of patients with ALL have a poor response to chemotherapy, this study aims to evaluate the effects of a iDNMT (Zebularine) associated with chemotherapy (mercaptopurine and methotrexate) ALL cell lines, as possible adjuvant therapy to acute lymphoblastic leukemia instead of conventional treatment. | |