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Evaluation of antineoplastic effects of Zebularine on childhood acute lymphoblastic leukemia cell lines.

Grant number: 10/14378-7
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Luiz Gonzaga Tone
Grantee:Augusto Faria Andrade
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood and represents a heterogeneous disease in relation to its biology and prognosis. The treatment is divided into remission induction therapy, intensification or consolidation and maintenance (administration of mercaptopurine and methotrexate). Despite advances in treatment about 20% of patients with disease recurrence and / or death indicating the need for different therapies for this group. Recently, drugs such epigenetic inhibitors of DNA-methyltransferase (iDNMTs) have shown anti-neoplastic and promising results for the treatment of several types of neoplasms including the LLA. Whereas a portion of patients with ALL have a poor response to chemotherapy, this study aims to evaluate the effects of a iDNMT (Zebularine) associated with chemotherapy (mercaptopurine and methotrexate) ALL cell lines, as possible adjuvant therapy to acute lymphoblastic leukemia instead of conventional treatment.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDRADE, AUGUSTO F.; BORGES, KLEITON S.; CASTRO-GAMERO, ANGEL M.; SILVEIRA, VANESSA S.; SUAZO, VERIDIANA K.; OLIVEIRA, JAQUELINE C.; MORENO, DANIEL A.; DE PAULA QUEIROZ, ROSANE G.; SCRIDELI, CARLOS A.; TONE, LUIZ G. Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells. ANTI-CANCER DRUGS, v. 25, n. 1, p. 72-81, JAN 2014. Web of Science Citations: 15.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANDRADE, Augusto Faria. Avaliação dos Efeitos Antineoplásicos da Zebularina em Linhagens Pediátricas de Leucemia Linfoide Aguda.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto Ribeirão Preto.

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