Exploratory analysis of the serum ionomic profile for bipolar disorder and lithium treatment

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Author(s):	Sussulini, Alessandra ; Banzato, Claudio E. M. ; Arruda, Marco A. Z. Total Authors: 3
Document type:	Journal article
Source:	INTERNATIONAL JOURNAL OF MASS SPECTROMETRY; v. 307, n. 1-3, p. 3-pg., 2011-10-01.
Abstract
In the present work, a very simple and fast experimental design using ICP-MS was employed to search for differentiations in the levels of free ions present in human blood serum samples obtained from healthy individuals (n = 25) and bipolar disorder (BD) patients under different treatments: (i) using lithium (n = 15) and (ii) using other drugs than lithium (n = 10). Fourteen ions that showed statistically significant alterations in its levels when comparing the studied groups were detected, providing a hint for further studies on BD and lithium treatment biomarker discovery. (C) 2010 Elsevier B.V. All rights reserved. (AU)