Microstructural Assessment of Cancellous Bone Using 3D Microtomography

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Silva, A. M. H. ; Alves, J. M. ; Da Silva, O. L. ; Silva Junior, N. F. ; Gazziro, M. ; Pereira, J. C. ; Lasso, P. R. O. ; Vaz, C. M. P. ; Pereira, C. A. M. ; Leiva, T. P. ; Guarniero, R. ; Rocha, D

• Document type: Journal article
• Source: WAKE CONFERENCE 2021; v. 313, p. 10-pg., 2011-01-01.

Abstract

Cancellous bones have a porous microstructure and can be modeled as linear elastic solid, heterogeneous and anisotropic. Few studies regarding the morphometric analysis of trabecular bone samples with 3D microtomography have been published so far. The technique has spread worldwide for the characterization of trabecular structures in studies related to bone quality and its relationship with metabolic diseases bone like osteoporosis. In our study cancellous bone samples with cubic and cylindrical geometry were extracted from bovine femur were used to investigate the structural arrangement of bone through high resolution x-ray 3D microtomography (mu CT). Four trabecular microstructural parameters (tissue volume, bone volume, bone volume fraction and tissue surface) were measured by 2D (stereological method) and 3D morphometric analysis using the software CTan Analyser supplied by the manufacturer of the microtomograph (SkyScan, model 1172, Belgium). The measurements were done in three main directions (superior-inferior, medial-lateral and anterior-posterior) to investigate the correlation between the 2D and 3D morphometric analysis. The results show a high correlation between the analysis. The x-ray 3D microtomography technique has a great potential for the assessment of bone quality. (AU)