Click Chemistry: An Efficient Synthesis of Heterocycles Substituted with Steroids, Saponins, and Digitalis Analogues

Author(s)

Deobald, Anna M. ; Camargo, Leandro R. S. ; Alves, Diego ; Zukerman-Schpector, Julio ; Correa, Arlene G. ; Paixao, Marcio W.

• Document type: Journal article
• Source: SYNTHESIS-STUTTGART; v. N/A, n. 24, p. 8-pg., 2011-12-01.

Abstract

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been used for the construction of 1,2,3-triazole containing steroids in good to excellent yields. Combination of propargylic glycosides and steroidal azides as reaction partner allowed the synthesis of a privileged class of natural product analogues. The versatility of this protocol makes this chemistry a useful attractive approach for the synthesis of target molecules. (AU)

• FAPESP's process: 09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
• Grantee: Márcio Weber Paixão
• Support Opportunities: Research Grants - Young Investigators Grants