| Full text | |
| Author(s): |
da Cruz, Adriana Taveira
;
Jasiulionis, Miriam Galvonas
Total Authors: 2
|
| Document type: | Journal article |
| Source: | DERMATOLOGY RESEARCH AND PRACTICE; v. 2012, p. 12-pg., 2012-01-01. |
| Abstract | |
miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of mRNAs are regulated by miRNAs. Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness. As miRNAs participate of virtually all cellular pathways, their deregulation is critical to cancer development. Consequently, loss or gain of miRNAs function may contribute to tumor progression. Little is known about the regulation of miRNAs and understanding the events that lead to changes in their expression may provide new perspectives for cancer treatment. Among distinct types of cancer, melanoma has special implications. It is characterized as a complex disease, originated from a malignant transformation of melanocytes. Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers. Some molecular pathways are frequently disrupted in melanoma, and miRNAs probably have a decisive role on these alterations. Therefore, this review aims to discuss new findings about miRNAs in melanoma fields, underlying epigenetic processes, and also to argue possibilities of using miRNAs in melanoma diagnosis and therapy. (AU) | |
| FAPESP's process: | 10/18484-6 - Identification of miRNA involved with melanoma genesis and epigenetic regulation of their expression |
| Grantee: | Adriana Taveira da Cruz |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 06/61293-1 - DNA methylation contribution to carcinogenesis |
| Grantee: | Miriam Galvonas Jasiulionis |
| Support Opportunities: | Research Grants - Young Investigators Grants |