N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study

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Maluf-Meiken, Leila C. V. ; Fernandes, Fernanda B. ; Aragao, Danielle S. ; Ronchi, Fernanda A. ; Andrade, Maria C. C. ; Franco, Maria C. ; Febba, Andreia C. S. ; Plavnik, Frida L. ; Krieger, Jose E. ; Mill, Jose G. ; Sesso, Ricardo C. C. ; Casarini, Dulce E.

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF HYPERTENSION; v. 2012, p. 9-pg., 2012-01-01.

Abstract

The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n = 1150) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n = 795), ACE 90(+) (65/90) (n = 186), and ACE 90(-) (65/190) (n = 169) based on the presence (+) or absence (-) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90(+) compared with the ACE 90(-) and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90(+) group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90- group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease. (AU)

• FAPESP's process: 02/13290-2 - Angiotensin I: converting enzyme isoform (90 kDa), potential genetic marker of hypertension: processing, molecular and functional characterization, and genetic segregation
• Grantee: Dulce Elena Casarini
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 10/51904-9 - Renin angiotensin and kallikrein kinin systems in hypertension, obesity, diabetes, desnutrition and sepsis: molecular, cellular and physiopathologic mechanisms
• Grantee: Dulce Elena Casarini
• Support Opportunities: Research Projects - Thematic Grants