Evaluation of an Experimental Gel Containing Euclea natalensis: An In Vitro Study

Author(s)

de Carvalho Sales-Peres, Silvia Helena ; de Freitas Brianezzi, Leticia Ferreira ; Marsicano, Juliane Avansini ; Forim, Moacir Rossi ; da Silva, Maria Fatima das Gracas Fernandes ; Sales-Peres, Arsenio

• Document type: Journal article
• Source: Evidence-based Complementary and Alternative Medicine; v. 2012, p. 6-pg., 2012-01-01.

Abstract

Objective. To evaluate the effect of an experimental gel containing Euclea natalensis extract on dentin permeability. Methods. Thirty-six dentin discs, 1-mm-thick. The discs were prepared from the coronal dentin of extracted human third molars that were divided into 3 groups (n = 10). The dentin discs in each group were treated with the groups following experimental materials: (FG): 1.23% fluoride gel, pH 4.1; (EG): Euclea natalensis extract gel, pH 4.1; (CG): control gel, pH 4.1. The gels were applied to the occlusal slide of the dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. The hydraulic conductance (HC) of each condition was determined four times using a fluid flow apparatus (Flodec). The data were analyzed using Two-way ANOVA and Tukey's test (P < 0.05). Results. The greatest mean reduction in HC was produced in group EG dentin discs (61.2%; P < 0.05). Even after acid challenge with 6% citric acid the great reduction occurred in group EG (66.0%; P < 0.05) than other groups (CG-77.1%, FG-90.8%). Conclusion. E. natalensis gel not only reduced dentin permeability, but also resisted posttreatment citric acid challenge without changing its permeability. Further research has to confirm this promising result in the clinical situation. (AU)

• FAPESP's process: 10/09951-0 - In vitro evaluation of the effect of a gel containing Euclea natalensis to reduce the dental erosion and dentin permeability
• Grantee: Silvia Helena de Carvalho Sales Peres
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/16079-0 - In vitro evaluation of the potential of the Euclea natalensis gel in reducing dentin permeability
• Grantee: Leticia Ferreira de Freitas Brianezzi
• Support Opportunities: Scholarships in Brazil - Scientific Initiation