Exploring the Role of Soluble Factors Associated with Immune Regulatory Properties of Mesenchymal Stem Cells

Author(s)

Bassi, Enio Jose ; de Almeida, Danilo Candido ; Mendes Moraes-Vieira, Pedro Manoel ; Saraiva Camara, Niels Olsen

• Document type: Journal article
• Source: STEM CELL REVIEWS AND REPORTS; v. 8, n. 2, p. 14-pg., 2012-06-01.

Abstract

Mesenchymal stem cells (MSCs) are characterized as multipotent stromal cells with the capacity for both self-renewal and differentiation into mesodermal cell lineages. MSCs also have a fibroblast-like phenotype and can be isolated from several tissues. In recent years, researchers have found that MSCs secrete several soluble factors that exert immunosuppressive effects by modulating both innate (macrophages, dendritic and NK cells) and adaptive (B cells and CD4+ and CD8+ T cells) immune responses. This review summarizes the principal trophic factors that are related to immune regulation and secreted by MSCs under both autoimmune and inflammatory conditions. The understanding of mechanisms that regulate immunity in MSCs field is important for their future use as a novel cellular-based immunotherapy with clinical applications in several diseases. (AU)

• FAPESP's process: 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 10/16213-5 - Global expression profile of microRNAs in tissue and cell repair induced by adipose tissue-derived mesenchymal stem cells.
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/12295-7 - MicroRNA profile during the repair of cisplatin-induced renal tissue and cells injury by therapy with mesenchymal stem cells derived from adipose tissue.
• Grantee: Danilo Candido de Almeida
• Support Opportunities: Scholarships in Brazil - Doctorate