The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models

• Grant number: 07/07139-3
• Support type: Research Projects - Thematic Grants
• Duration: June 01, 2008 - May 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Niels Olsen Saraiva Câmara
• Grantee: Niels Olsen Saraiva Câmara
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Principal researchers: Wothan Tavares de Lima
• Assoc. researchers: Alexandre Learth Soares ; Alvaro Pacheco e Silva Filho ; Ana Cristina Breithaupt Faloppa ; Bernardo Boris Jorge Vargaftig ; Carla Quarim Feitoza ; Dario Simões Zamboni ; Eduardo Rocha ; Fernando Rodrigues Coelho ; Gabriela Campanholle ; Georgia Daniela Marcusso Marques ; Giancarlo Zanoli Trentim ; Giselle Martins Gonçalves ; Marcelo Torres Bozza ; Mariane Tami Amano ; Marilda Mazzali ; Mayra Carvalho Ribeiro ; Pamella Huey Mei Wang ; Patricia Semedo Kuriki ; Paulo Guilherme Renesto ; Rafael Assumpção Larocca ; Rebecca Midory Marques Monteiro ; Richardt Gama Landgraf ; Vanessa Nunes de Paiva
• Associated scholarship(s): 11/22568-3 - Renoprotective mechanisms of stem cells derived from adipose tissue in experimental models of chronic kidney disease in vivo and in vitro, BP.DD; 11/14613-9 - Role of IFNg in the activation of mesenchymal stem cells: analysis in a model of acute kidney injury, BP.MS; 11/15682-4 - Sepsis and Obesity: study of the relationship between obesity and immune regulation in an experimental model of sepsis, BP.DR; + associated scholarships 11/03833-8 - The role of Tlr-2, Tlr-4 and MyD88 in the development of experimental autoimmune diabetes, BP.MS; 11/01016-2 - Short Chain Fatty Acid as modulators of the inflammatory response in chronic and acute experimental kidney injuries, BP.DR; 10/12295-7 - MicroRNA profile during the repair of cisplatin-induced renal tissue and cells injury by therapy with mesenchymal stem cells derived from adipose tissue., BP.DR; 10/02024-6 - MODULATION OF ENDOTHELIAL TO MESENCHYMAL TRANSITION BY HEME OXYGENASE 1: RELEVANCE TO THE STUDY OF PROGRESSION OF RENAL DISEASES., BP.DR; 09/13251-6 - Role of stem cells derived from adipose tissue in the progression of renal disease, BP.MS; 09/06416-9 - The role of conditioned medium of mesenchymal stem cells on apoptose process of proximal tubular cells induced by hypoxia, BP.MS; 09/06537-0 - Global genomic analysis of IgA nephropathy in native kidneys in patients with recurrent /"de novo" disease after renal transplant, BP.PD; 09/50450-7 - Adipokines in experimental transplantation: interaction between leptin and the development of immunological tolerance, BP.DR - associated scholarships

Abstract

Recently, our group is developing several researches to characterize the inflammatory response in different renal diseases, by using experimental model and human samples analyses approaches. Renal diseases present an enormous socio-economic impact and a great morbid-mortality for patients. In this sense, new knowledge about their physiopathogeny that promotes better renal function outcome is necessary to improve patient survival. So far, the results obtained during these years indicate that innate and adaptive immune responses, such as endothelial cell activation, synthesis of cyclooxygenase, Bradykinin production, and CD4+ T cell are effector mechanisms of acute renal injury. However, in all studied models, it was seen that the tissue response face aggression is also relevant, and relies on expression of several so called protective genes, among them, the heme oxygenase 1 (HO-1). Besides, HO-1 being a stress-inducible protein, and its modulation can be associated to better organ function, its expression can be linked to the innate immune response toward a danger, intimately. The action of HO-1 on the innate immunity could be transferred to the adaptive part and generate nonresponsive T cells, and therefore, less tissue damage. Furthermore, here we propose to study other renal injuries than ischemia, demonstrating that this hypothesis could be applied to renal inflammatory disease in a broad sense. Finally, we hope to show that the immune response triggered by renal diseases in systemic, and could generate a positive feedback loop. In this project, we intend to study deeper the role of HO-1 in renal injuries, in different animal models and in cell culture systems. By doing that, we intend to answer our hypotheses and aims. (AU)

Scientific publications

(40)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE-SILVA, MAGAIVER; CENEDEZE, MARCOS ANTONIO; PERANDINI, LUIZ AUGUSTO; FERREIRA FELIZARDO, RAPHAEL JOSE; MIZUNO WATANABE, INGRID KAZUE; HENAO AGUDELO, JUAN SEBASTIAN; CASTOLDI, ANGELA; GONCALVES, GISELLE MARTINS; TAEMI ORIGASSA, CLARICE SILVIA; SEMEDO, PATRICIA; HIYANE, MEIRE IOSHIE; FORESTO-NETO, ORESTES; AVANCINI COSTA MALHEIROS, DENISE MARIA; REIS, MARLENE ANTONIA; FUJIHARA, CLARICE KAZUE; ZATZ, ROBERTO; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN; DE ALMEIDA, DANILO CANDIDO. TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury. Clinical Science, v. 132, n. 16, p. 1725-1739, AUG 31 2018. Web of Science Citations: 9.

DE OLIVEIRA, DANIEL MAY; LOBATO DE OLIVEIRA, ENEDINA MARIA; RAMIRES FERRARI, MERARI DE FATIMA; SEMEDO, PATRICIA; HIYANE, MEIRE IOSHIE; CENEDEZE, MARCOS ANTONIO; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN; SCHATZMANN PERON, JEAN PIERRE. Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration. INFLAMMOPHARMACOLOGY, v. 23, n. 6, p. 343-354, DEC 2015. Web of Science Citations: 11.

AGUIAR, CRISTHIANE FAVERO; NAFFAH-DE-SOUZA, CRISTIANE; CASTOLDI, ANGELA; CORREA-COSTA, MATHEUS; BRAGA, TARCIO T.; NAKA, ERIKA L.; AMANO, MARIANE T.; ABATE, DEBORA T. R. S.; HIYANE, MEIRE I.; CENEDEZE, MARCOS A.; PACHECO E SILVA FILHO, ALVARO; CAMARA, NIELS O. S. Administration of alpha-Galactosylceramide Improves Adenine-Induced Renal Injury. Molecular Medicine, v. 21, p. 553-562, 2015. Web of Science Citations: 5.

PEREIRA, RAFAEL LUIZ; FERREIRA FELIZARDO, RAPHAEL JOSE; CENEDEZE, MARCOS ANTOINO; HIYANE, MEIRE IOSHIE; BASSI, ENIO JOSE; AMANO, MARIANE TAMI; TAEMI ORIGASSA, CLARICE SYLVIA; SILVA, REINALDO CORREIA; AGUIAR, CRISTHIANE FAVERO; CARNEIRO, SYLVIA MENDES; PESQUERO, JOAO BOSCO; ARAUJO, RONALDO CARVALHO; KELLER, ALEXANDRE DE CASTRO; MONTEIRO, RENATO C.; MOURA, IVAN CRUZ; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice. Disease Models & Mechanisms, v. 7, n. 6, p. 701-710, JUN 2014. Web of Science Citations: 6.

LAROCCA, RAFAEL ASSUMPCAO; MORAES-VIEIRA, PEDRO MANOEL; BASSI, ENIO JOSE; SEMEDO, PATRICIA; DE ALMEIDA, DANILO CANDIDO; DA SILVA, MARINA BURGOS; THORNLEY, THOMAS; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Adipose Tissue-Derived Mesenchymal Stem Cells Increase Skin Allograft Survival and Inhibit Th-17 Immune Response. PLoS One, v. 8, n. 10 OCT 4 2013. Web of Science Citations: 24.

MORAES-VIEIRA, P. M. M.; BASSI, E. J.; LAROCCA, R. A.; CASTOLDI, A.; BURGHOS, M.; LEPIQUE, A. P.; QUINTANA, F. J.; ARAUJO, R. C.; BASSO, A. S.; STROM, T. B.; CAMARA, N. O. S. Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile. AMERICAN JOURNAL OF TRANSPLANTATION, v. 13, n. 1, p. 36-44, JAN 2013. Web of Science Citations: 24.

SILVA, REINALDO C.; LANDGRAF, MARISTELLA A.; CORREA-COSTA, MATHEUS; SEMEDO, PATRICIA; CENEDEZE, MARCOS A.; PACHECO-SILVA, ALVARO; LANDGRAF, RICHARDT G.; CAMARA, NIELS O. S. Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 31, n. 2-3, p. 179-188, 2013. Web of Science Citations: 8.

BASSI, ENIO J.; MORAES-VIEIRA, PEDRO M. M.; MOREIRA-SA, CARLA S. R.; ALMEIDA, DANILO C.; VIEIRA, LEONARDO M.; CUNHA, CLAUDIA S.; HIYANE, MEIRE I.; BASSO, ALEXANDRE S.; PACHECO-SILVA, ALVARO; CAMARA, NIELS O. S. Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes. Diabetes, v. 61, n. 10, p. 2534-2545, OCT 2012. Web of Science Citations: 75.

ELIAS, ROSA MARIA; CORREA-COSTA, MATHEUS; BARRETO, CLAUDIENE RODRIGUES; SILVA, REINALDO CORREIA; HAYASHIDA, CAROLINE Y.; CASTOLDI, ANGELA; GONCALVES, GISELLE MARTINS; BRAGA, TARCIO TEODORO; BARBOZA, RENATO; RIOS, FRANCISCO JOSE; KELLER, ALEXANDRE CASTRO; CENEDEZE, MARCOS ANTONIO; HYANE, MEIRE IOSHIE; D'IMPERIO-LIMA, MARIA REGINA; FIGUEIREDO-NETO, ANTONIO MARTINS; REIS, MARLENE ANTONIA; FARIAS MARINHO, CLAUDIO ROMERO; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection. PLoS One, v. 7, n. 8 AUG 31 2012. Web of Science Citations: 20.

CORREA-COSTA, MATHEUS; LANDGRAF, MARISTELLA A.; CAVANAL, MARIA F.; SEMEDO, PATRICIA; VIEIRA, DANIEL A. G.; DE MARCO, DAVI T. K.; HIRATA, APARECIDA E.; CAMARA, NIELS O. S.; GIL, FRIDA Z. Inflammatory milieu as an early marker of kidney injury in offspring rats from diabetic mothers. European Journal of Pharmacology, v. 689, n. 1-3, p. 233-240, AUG 15 2012. Web of Science Citations: 6.

BRAGA, TARCIO TEODORO; CORREA-COSTA, MATHEUS; SOUZA GUISE, YURI FELIPE; CASTOLDI, ANGELA; DE OLIVEIRA, CASSIANO DONIZETTI; HYANE, MEIRE IOSHIE; CENEDEZE, MARCOS ANTONIO; TEIXEIRA, SIMONE APARECIDA; MUSCARA, MARCELO NICOLAS; PEREZ, KATIA REGINA; CUCCOVIA, IOLANDA MIDEA; PACHECO-SILVA, ALVARO; GONCALVES, GISELLE MARTINS; SARAIVA CAMARA, NIELS OLSEN. MyD88 Signaling Pathway Is Involved in Renal Fibrosis by Favoring a T(H)2 Immune Response and Activating Alternative M2 Macrophages. Molecular Medicine, v. 18, n. 8, p. 1231-1239, AUG 2012. Web of Science Citations: 55.

MORAES-VIEIRA, P. M. M.; BASSI, E. J.; ARAUJO, R. C.; CAMARA, N. O. S. Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?. Obesity Reviews, v. 13, n. 8, p. 733-743, AUG 2012. Web of Science Citations: 16.

BREITHAUPT-FALOPPA, ANA CRISTINA; VITORETTI, LUANA BEATRIZ; CAVRIANI, GABRIELA; LINO-DOS-SANTOS-FRANCO, ADRIANA; SUDO-HAYASHI, LIA SIGUEMI; OLIVEIRA-FILHO, RICARDO MARTINS; BORIS VARGAFTIG, B.; TAVARES-DE-LIMA, WOTHAN. Intestinal Lymph-Borne Factors Induce Lung Release of Inflammatory Mediators and Expression of Adhesion Molecules After an Intestinal Ischemic Insult. JOURNAL OF SURGICAL RESEARCH, v. 176, n. 1, p. 195-201, JUL 2012. Web of Science Citations: 9.

CASTOLDI, ANGELA; BRAGA, TARCIO TEODORO; CORREA-COSTA, MATHEUS; AGUIAR, CRISTHIANE FAVERO; BASSI, ENIO JOSE; CORREA-SILVA, REINALDO; ELIAS, ROSA MARIA; SALVADOR, FABIA; MORAES-VIEIRA, PEDRO MANOEL; CENEDEZE, MARCOS ANTONIO; REIS, MARLENE ANTONIA; HIYANE, MEIRE IOSHIE; PACHECO-SILVA, ALVARO; GONCALVES, GISELLE MARTINS; SARAIVA CAMARA, NIELS OLSEN. TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis. PLoS One, v. 7, n. 5 MAY 24 2012. Web of Science Citations: 62.

BASSI, ENIO JOSE; DE ALMEIDA, DANILO CANDIDO; MENDES MORAES-VIEIRA, PEDRO MANOEL; SARAIVA CAMARA, NIELS OLSEN. Exploring the Role of Soluble Factors Associated with Immune Regulatory Properties of Mesenchymal Stem Cells. STEM CELL REVIEWS AND REPORTS, v. 8, n. 2, p. 329-342, 2012. Web of Science Citations: 44.

CAMPANHOLLE, GABRIELA; SILVA, REINALDO C.; MARTINS, JOILSON O.; LANDGRAF, MARISTELLA A.; PAIVA, VANESSA N.; FERREIRA, RENAIDE R.; AMANO, MARIANE T.; HIYANE, MEIRE I.; CENEDEZE, MARCOS A.; PACHECO-SILVA, ALVARO; CAMARA, NIELS O. S.; LANDGRAF, RICHARDT G. Modulation of Lung Allergic Response by Renal Ischemia and Reperfusion Injury. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 29, n. 3-4, p. 523-532, 2012. Web of Science Citations: 2.

DONIZETTI-OLIVEIRA, CASSIANO; SEMEDO, PATRICIA; BURGOS-SILVA, MARINA; CENEDEZE, MARCO ANTONIO; AVANCINI COSTA MALHEIROS, DENISE MARIA; REIS, MARLENE A.; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Adipose Tissue-Derived Stem Cell Treatment Prevents Renal Disease Progression. CELL TRANSPLANTATION, v. 21, n. 8, p. 1727-1741, 2012. Web of Science Citations: 43.

LANDGRAF, MARISTELLA A.; LANDGRAF, RICHARDT G.; SILVA, REINALDO C.; SEMEDO, PATRICIA; CAMARA, NIELS O. S.; FORTES, ZULEICA B. Intrauterine Undernourishment Alters TH1/TH2 Cytokine Balance and Attenuates Lung Allergic Inflammation in Wistar Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 30, n. 3, p. 552-562, 2012. Web of Science Citations: 7.

CORREA-COSTA, MATHEUS; BRAGA, TARCIO TEODORO; SEMEDO, PATRICIA; HAYASHIDA, CAROLINE YURI; GRASSMANN BECHARA, LUIZ ROBERTO; ELIAS, ROSA MARIA; BARRETO, CLAUDIENE RODRIGUES; SILVA-CUNHA, CLAUDIA; HYANE, MEIRE IOSHIE; GONCALVES, GISELLE MARTINS; BRUM, PATRICIA CHAKUR; FUJIHARA, CLARICE; ZATZ, ROBERTO; PACHECO-SILVA, ALVARO; ZAMBONI, DARIO S.; SARAIVA CAMARA, NIELS OLSEN. Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis. PLoS One, v. 6, n. 12 DEC 14 2011. Web of Science Citations: 47.

PEREIRA, RAFAEL L.; BUSCARIOLLO, BRUNA N.; CORREA-COSTA, MATHEUS; SEMEDO, PATRICIA; OLIVEIRA, CASSIANO D.; REIS, VANESSA O.; MAQUIGUSSA, EDGAR; ARAUJO, RONALDO C.; BRAGA, TARCIO T.; SOARES, MARIA F.; MOURA, IVAN C.; MALHEIROS, DENISE M. A. C.; PACHECO-SILVA FILHO, ALVARO; KELLER, ALEXANDRE C.; CAMARA, NIELS O. S. Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis. Kidney International, v. 79, n. 11, p. 1217-1227, JUN 2011. Web of Science Citations: 16.

GONCALVES, G. M.; CASTOLDI, A.; BRAGA, T. T.; CAMARA, N. O. S. New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries. Scandinavian Journal of Immunology, v. 73, n. 5, p. 428-435, MAY 2011. Web of Science Citations: 28.

CASSIANO DONIZETTI-OLIVEIRA; PATRICIA SEMEDO; MARINA BURGOS-SILVA; MARCO ANTONIO CENEDEZE; DENISE MARIA AVANCINI COSTA MALHEIROS; MARLENE ANTÔNIA DOS REIS; ALVARO PACHECO-SILVA; NIELS OLSEN SARAIVA CÂMARA. Role of adipose tissue-derived stem cells in the progression of renal disease. Einstein (São Paulo), v. 9, n. 1, p. 36-45, Mar. 2011.

NOGUEIRA, ELIANA; SALOMAO, REINALDO; COLLO BRUNIALTI, MILENA KARINA; OZAKI, KIKUMI S.; MARQUES, GEORGIA D. M.; CENEDEZE, MARCOS A.; SARAIVA CAMARA, NIELS OLSEN; PACHECO-SILVA, ALVARO. Expression of TLR-4 and -2 in peripheral mononuclear cells in renal transplant patients with TLR-4 gene polymorphism. International Immunopharmacology, v. 10, n. 12, SI, p. 1481-1485, DEC 2010. Web of Science Citations: 6.

CAMPANHOLLE, G.; LANDGRAF, R. G.; GONCALVES, G. M.; PAIVA, V. N.; MARTINS, J. O.; WANG, P. H. M.; MONTEIRO, R. M. M.; SILVA, R. C.; CENEDEZE, M. A.; TEIXEIRA, V. P. A.; REIS, M. A.; PACHECO-SILVA, A.; JANCAR, S.; SARAIVA CAMARA, NIELS OLSEN. Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. Inflammation Research, v. 59, n. 10, p. 861-869, OCT 2010. Web of Science Citations: 17.

GONCALVES, GISELLE MARTINS; ZAMBONI, DARIO S.; SARAIVA CAMARA, NIELS OLSEN. THE ROLE OF INNATE IMMUNITY IN SEPTIC ACUTE KIDNEY INJURIES. Shock, v. 34, n. 1, p. 22-26, SEP 2010. Web of Science Citations: 42.

CAMPANHOLLE, GABRIELA; LANDGRAF, RICHARDT G.; BORDUCCHI, ERICA; SEMEDO, PATRICIA; WANG, PAMELA H. M.; AMANO, MARIANE T.; RUSSO, MOMTCHILO; PACHECO-SILVA, ALVARO; JANCAR, SONIA; CAMARA, NIELS O. S. Bradykinin inducible receptor is essential to lipopolysaccharide-induced acute lung injury in mice. European Journal of Pharmacology, v. 634, n. 1-3, p. 132-137, MAY 25 2010. Web of Science Citations: 10.

SEMEDO, PATRICIA; DONIZETTI-OLIVEIRA, CASSIANO; BURGOS-SILVA, MARINA; CENEDEZE, MARCO ANTONIO; AVANCINI COSTA MALHEIROS, DENISE MARIA; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Bone marrow mononuclear cells attenuate fibrosis development after severe acute kidney injury. LABORATORY INVESTIGATION, v. 90, n. 5, p. 685-695, MAY 2010. Web of Science Citations: 25.

FEITOZA, CARLA Q.; SEMEDO, PATRICIA; GONCALVES, GISELLE M.; CENEDEZE, MARCOS A.; PINHEIRO, HELADY S.; PAVAO DOS SANTOS, OSCAR FERNANDO; LANDGRAF, RICHARDT GAMA; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury. Inflammation Research, v. 59, n. 3, p. 167-175, MAR 2010. Web of Science Citations: 12.

CORREA-COSTA, MATHEUS; SEMEDO, PATRICIA; MONTEIRO, ANA PAULA F. S.; SILVA, REINALDO C.; PEREIRA, RAFAEL L.; GONCALVES, GISELLE M.; MARCUSSO MARQUES, GEORGIA DANIELA; CENEDEZE, MARCOS A.; FALEIROS, ANA C. G.; KELLER, ALEXANDRE C.; SHIMIZU, MARIA H. M.; SEGURO, ANTONIO C.; REIS, MARLENE A.; PACHECO-SILVA, ALVARO; CAMARA, NIELS O. S. Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis. PLoS One, v. 5, n. 12, p. e14298, 2010. Web of Science Citations: 48.

SILVA, REINALDO C.; LANDGRAF, MARISTELLA A.; HIYANE, MEIRE I.; PACHECO-SILVA, ALVARO; CAMARA, NIELS O.; LANDGRAF, RICHARDT G. Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 26, n. 3, p. 319-326, 2010. Web of Science Citations: 8.

SEMEDO, PATRICIA; CORREA-COSTA, MATHEUS; CENEDEZE, MARCOS ANTONIO; AVANCINI COSTA MALHEIROS, DENISE MARIA; DOS REIS, MARLENE ANTONIA; SHIMIZU, MARIA HELOISA; SEGURO, ANTONIO CARLOS; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Mesenchymal Stem Cells Attenuate Renal Fibrosis Through Immune Modulation and Remodeling Properties in a Rat Remnant Kidney Model. Stem Cells, v. 27, n. 12, p. 3063-3073, DEC 2009. Web of Science Citations: 167.

GENRE, J.; ERRANTE, P. R.; KOKRON, C. M.; TOLEDO-BARROS, M.; CAMARA, N. O. S.; RIZZO, L. V. Reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?. Clinical Immunology, v. 132, n. 2, p. 215-221, AUG 2009. Web of Science Citations: 48.

MESQUITA, JR., D.; CRUVINEL, W. M.; CAMARA, N. O. S.; KALLAS, E. G.; ANDRADE, L. E. C. Autoimmune diseases in the TH17 era. Brazilian Journal of Medical and Biological Research, v. 42, n. 6, p. 476-486, JUN 2009. Web of Science Citations: 18.

ALEXANDRE‚ C.S.; VOLPINI‚ R.A.; SHIMIZU‚ M.H.; SANCHES‚ T.R.; SEMEDO‚ P.; DI JURA‚ V.L.; CAMARA‚ N.O.; SEGURO‚ A.C.; ANDRADE‚ L. Lineage-Negative Bone Marrow Cells Protect Against Chronic Renal Failure. Stem Cells, v. 27, n. 3, p. 682-692, 2009.

MEI WANG, PAMELLA HUEY; SCHWINDT, TELMA T.; BARNABE, GABRIELA FILOSO; MOTTA, FABIANA L. T.; SEMEDO, PATRICIA; BERALDO, FELIPE CAETANO; MAZZALI, MARILDA; DOS REIS, MARLENE ANTONIA; ANTUNES TEIXEIRA, VICENTE DE PAULA; PACHECO-SILVA, ALVARO; DE MELLO, LUIS EUGENIO A.; CAMARA, NIELS O. S. Administration of Neural Precursor Cells Ameliorates Renal Ischemia-Reperfusion Injury. NEPHRON EXPERIMENTAL NEPHROLOGY, v. 112, n. 1, p. E20-E28, 2009. Web of Science Citations: 7.

MONTEIRO‚ R.M.M.; CAMARA‚ N.O.S.; RODRIGUES‚ M.M.; TZELEPIS‚ F.; DAMIÃO‚ M.J.; CENEDEZE‚ M.A.; TEIXEIRA‚ V.P.A.; DOS REIS‚ M.A.; PACHECO-SILVA‚ A. A role for regulatory T cells in renal acute kidney injury. TRANSPLANT IMMUNOLOGY, v. 21, n. 1, p. 50-55, 2009.

NAKA‚ E.L.; PONCIANO‚ V.C.; CENEDEZE‚ M.A.; PACHECO-SILVA‚ A.; SARAIVA CÂMARA‚ N.O. Detection of the Tim-3 ligand‚ galectin-9‚ inside the allograft during a rejection episode. International Immunopharmacology, v. 9, n. 6, p. 658-662, 2009.

WANG‚ P.H.M.; CENEDEZE‚ M.A.; CAMPANHOLLE‚ G.; MALHEIROS‚ D.M.A.C.; DE MOURA TORRES‚ H.A.; PESQUERO‚ J.B.; PACHECO-SILVA‚ A.; C{\=A}MARA‚ N.O.S. Deletion of bradykinin B1 receptor reduces renal fibrosis. International Immunopharmacology, v. 9, n. 6, p. 653-657, 2009.

FEITOZA, CARLA Q.; GONALVES, GISELLE M.; SEMEDO, PATRICIA; CENEDEZE, MARCOS A.; PINHEIRO, HELADY S.; BERALDO, FELIPE CAETANO; DOS SANTOS, OSCAR FERNANDO PAVAO; TEIXEIRA, VICENTE DE PAULA A.; DOS REIS, MARLENE A.; MAZZALI, MARILDA; PACHECO-SILVA, ALVARO; CAMARA, NIELS O. S. Inhibition of COX 1 and 2 prior to Renal Ischemia/Reperfusion Injury Decreases the Development of Fibrosis. Molecular Medicine, v. 14, n. 11-12, p. 724-730, NOV-DEC 2008. Web of Science Citations: 41.

WANG, PAMELLA H. M.; CAMPANHOLLE, GABRIELA; CENEDEZE, MARCOS A.; FEITOZA, CARLA Q.; GONCALVES, GISELLE M.; LANDGRAF, RICHARDT G.; JANCAR, SONIA; PESQUERO, JOAO B.; PACHECO-SILVA, ALVARO; CAMARA, NIELS O. S. Brabykinin B1 Receptor Antagonism Is Beneficial in Renal Ischemia-Reperfusion Injury. PLoS One, v. 3, n. 8, p. e3050, 2008. Web of Science Citations: 23.